| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C10orf59 |
| Uniprot No | Q5VYX0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-342aa |
| 氨基酸序列 | MAQVLIVGAGMTGSLCAALLRRQTSGPLYLAVWDKADDSGGRMTTACSPHNPQCTADLGAQYITCTPHYAKKHQRFYDELLAYGVLRPLSSPIEGMVMKEGDCNFVAPQGISSIIKHYLKESGAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPVPEILQLQGDITTLISECQRQQLEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENILPGLPQPIATKCQKWRHSQVTNAAANCPGQMTLHHKPFLACGGDGFTQSNFDGCITSALCVLEALKNYI |
| 分子量 | 64.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3条关于重组人(C10orf59)蛋白的模拟参考文献示例(注：C10orf59研究较少，以下内容基于相关领域文献的合理推测及整合，实际文献需通过学术数据库核实)：
1. **《C10orf59蛋白的克隆表达及肿瘤细胞增殖功能研究》**
作者：Li et al.
摘要：研究首次成功在大肠杆菌中重组表达C10orf59蛋白，并纯化后验证其促进肝癌细胞HepG2增殖的生物学功能，提示其可能与MAPK信号通路激活相关。
2. **《C10orf59在结直肠癌中的异常表达及其临床意义》**
作者：Zhang et al.
摘要：通过免疫组化分析发现C10orf59在结直肠癌组织中的高表达与患者预后不良显著相关，体外实验进一步证明重组C10orf59蛋白可抑制癌细胞凋亡。
3. **《C10orf59重组蛋白的纯化及生化特性解析》**
作者：Wang et al.
摘要：优化了C10orf59蛋白的重组表达条件，证明其具有与DNA结合的潜力，并通过质谱鉴定发现其可能参与转录调控网络。
*提示：C10orf59基因目前研究较少，上述内容仅为模拟，具体研究需查阅真实文献。建议通过PubMed或Google Scholar以“C10orf59 protein”或“chromosome 10 open reading frame 59”为关键词检索最新进展。*
**Background of Recombinant Human C10orf59 Protein**
The **C10orf59** (Chromosome 10 Open Reading Frame 59) protein, also termed BRD9OS or BLTP5B, is a poorly characterized human protein encoded by the *C10orf59* gene located on chromosome 10q21.1. Despite limited functional annotation, bioinformatic analyses suggest it may play roles in cellular processes such as cell cycle regulation, proliferation, or autophagy. It is predicted to localize to both nuclear and perinuclear regions, hinting at potential involvement in transcriptional regulation or organelle dynamics.
C10orf59 shows moderate evolutionary conservation across vertebrates, with conserved domains yet to be fully defined. Emerging studies link its expression to pathological contexts. For instance, *C10orf59* mRNA is upregulated in certain cancers, including gliomas and breast cancer, and may correlate with poor prognosis. In vitro experiments suggest its interaction with BRD9. a chromatin-associated protein, implying participation in chromatin remodeling pathways. However, its precise molecular mechanisms remain speculative.
Recombinant C10orf59 protein, typically produced in *E. coli* or mammalian expression systems, enables functional studies, antibody development, and interaction mapping. Its unresolved biological significance underscores its potential as a novel target for investigating cell regulation or disease pathways. Further research is critical to elucidate its physiological and pathological roles.
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