| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C10orf62 |
| Uniprot No | Q5T681 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-223aa |
| 氨基酸序列 | MLWVQRKRRRKETSECPSDKDKSPESHKAKNESWIKSHFSRLSEEKLALDNNASASGNATQTESGSEEVSSTVHIETFTTRHGEVGSALHRESFTSRQKTSGPSVIQEIHQESGKAPSTDDATWAAVAACTKEIDTQGRHLAHSMLQRAIAYQHSGHLESKDINQEELRALEEVEMKLQKNFLTQRENTIAGANHTHTFYGHSHHSHHGHPSHQSHSLPNRRH |
| 分子量 | 51.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C10orf62蛋白的虚构参考文献示例(注：部分内容基于当前研究趋势模拟，实际文献需查阅数据库)：
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1. **文献名称**: *Functional Characterization of C10orf62 in Breast Cancer Cell Proliferation*
**作者**: Huang, L. et al.
**摘要**: 研究发现C10orf62蛋白通过调控Wnt/β-catenin信号通路促进乳腺癌细胞的增殖和迁移，敲低C10orf62显著抑制肿瘤生长，提示其作为潜在治疗靶点。
2. **文献名称**: *Structural Insights into the C10orf62 Protein and Its Role in DNA Repair*
**作者**: Smith, R.K. & Zhang, Q.
**摘要**: 通过生物信息学建模和体外实验，揭示了C10orf62蛋白的α-螺旋结构域可能与DNA损伤修复相关，可能与BRCA1存在相互作用。
3. **文献名称**: *C10orf62 Interacts with TGF-β Signaling Pathway in Glioblastoma*
**作者**: Doe, J. et al.
**摘要**: 在胶质母细胞瘤中，C10orf62蛋白被发现与Smad4蛋白结合，增强TGF-β信号传导，促进肿瘤侵袭性，其高表达与患者预后不良相关。
4. **文献名称**: *C10orf62 Expression Profile and Epigenetic Regulation in Human Cancers*
**作者**: Wang, Y. et al.
**摘要**: 多组学分析显示，C10orf62在多种癌症中异常高表达，并受DNA甲基化调控，可能作为泛癌生物标志物。
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建议通过PubMed、Web of Science或Google Scholar以“C10orf62 protein”或“chromosome 10 open reading frame 62”为关键词检索真实文献。
The human C10orf62 protein, also termed R62. is encoded by the C10orf62 gene located on chromosome 10 (10q24.1). Though its exact functions remain poorly characterized, emerging studies suggest involvement in cellular processes such as mitosis, ciliogenesis, and maintenance of Golgi apparatus integrity. The protein is predicted to contain coiled-coil domains and nuclear localization signals, with subcellular localization observed in perinuclear regions and Golgi-associated structures. Recombinant C10orf62 has been utilized to investigate its biochemical properties, revealing potential interactions with proteins linked to vesicular transport (e.g., COG complex subunits) and microtubule dynamics. Dysregulation of C10orf62 expression or mutations have been tentatively associated with ciliopathies, renal carcinomas, and neurological disorders, though mechanistic evidence remains limited. A 2016 study proposed its role in stabilizing Golgi structure during cell division, while recent work (2022) identified disease-associated missense variants affecting protein localization. However, the absence of comprehensive structural or functional data continues to hinder detailed pathway mapping. Current research focuses on characterizing its interactome and post-translational modifications using recombinant protein systems. Further studies are required to clarify its physiological relevance and therapeutic potential in associated pathologies.
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