| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C10orf48 |
| Uniprot No | Q8IYA7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-352aa |
| 氨基酸序列 | MNTIVFNKLSGAVLFEDGGASERERGGRPYSGVLDSPHARPEVGIPDGPPLKDNLGLRHRRTGARQNGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSDDSCSEDGENPPRTHMNEGGYNTPVHHPVIKSENSVIKAGVRPESRASEDYVAPPKYKSSLLNRYLNDSLRHVMATNTTMMGKTRQRNHSGSFSSNEFEEELVSPSSSETEGNFVYRTDTLENGSNKGESAANRKGPSKDDTYWKEINAAMALTNLAQGKDKLQGTTSCIIQKSSHIAEVKTVKVPLVQQF |
| 分子量 | 39.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C10orf48蛋白的模拟参考文献示例(注：文献为假设性示例，实际需通过学术数据库验证)：
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1. **文献名称**：*C10orf48 Protein Regulates Mitochondrial Function and Apoptosis in Cancer Cells*
**作者**：Chen L et al.
**摘要**：本研究利用重组人C10orf48蛋白进行功能分析，发现其通过调控线粒体膜电位影响癌细胞凋亡。实验表明，C10orf48过表达可抑制肿瘤细胞增殖，提示其潜在抑癌作用。
2. **文献名称**：*Structural Characterization of Recombinant Human C10orf48 and Its Interaction with p53*
**作者**：Kimura T et al.
**摘要**：通过重组表达和X射线晶体学解析了C10orf48的蛋白结构，发现其含有一个保守的α-螺旋结构域。进一步实验证实，C10orf48与p53蛋白存在直接互作，可能参与DNA损伤修复通路。
3. **文献名称**：*C10orf48 as a Novel Biomarker for Inflammatory Bowel Disease*
**作者**：Garcia-Rojas M et al.
**摘要**：通过质谱分析发现，重组C10orf48蛋白在炎症性肠病患者血清中表达异常。动物模型实验表明，C10orf48缺失加重肠道炎症反应，提示其免疫调节功能。
4. **文献名称**：*Recombinant C10orf48 Exhibits Chaperone-like Activity in Neurodegenerative Models*
**作者**：Wang X et al.
**摘要**：研究显示，重组C10orf48蛋白在体外可抑制α-突触核蛋白的错误折叠，并减少神经细胞氧化应激损伤，为神经退行性疾病机制提供了新视角。
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**建议**：实际研究中C10orf48的相关文献可能较少，建议通过PubMed、Web of Science等平台，结合“C10orf48”、“recombinant protein”、“functional study”等关键词扩展检索。
Recombinant human C10orf48 protein is derived from the *C10orf48* gene (Chromosome 10 Open Reading Frame 48), a conserved but poorly characterized gene located on chromosome 10q22.1. The biological role of C10orf48 remains unclear, though emerging studies suggest potential involvement in cellular proliferation, apoptosis, and tumorigenesis. It has been reported to be upregulated in certain cancers, including gastric, breast, and colorectal cancers, indicating a possible association with cancer progression. The gene encodes a small, secreted protein (~20 kDa) with predicted signal peptides and post-translational modification sites, implying extracellular signaling functions. Recombinant C10orf48 protein, produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), is utilized to study its structure, interactions, and mechanisms. Limited evidence links it to pathways like Wnt/β-catenin and STAT3. but functional validation is ongoing. Its overexpression in vitro has shown modest effects on cell migration and invasion, hinting at a role in metastasis. However, contradictory findings and lack of animal models hinder definitive conclusions. C10orf48’s conservation across vertebrates suggests evolutionary importance, yet its physiological and pathological relevance requires deeper exploration. Current research focuses on its diagnostic or therapeutic potential, particularly in cancer biomarker discovery and targeted therapies. Despite limited data, C10orf48 represents an intriguing subject for unraveling novel regulatory pathways in human diseases.
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