| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C10orf46 |
| Uniprot No | Q86Y37 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-369aa |
| 氨基酸序列 | MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR EPPGGQLLAV PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV AKAAPAPTAS STININTSTS KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ SPGDYIPISY EQIYSCVYKC VCQQHSEQMY SDLIKKITNH LERVSKELQA SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL NRDLKDDLIK LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA GDELAYNSSS ACASSRGYR |
| 分子量 | 41 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白 **C10orf46** 的参考文献示例(注：由于该蛋白研究较少，部分文献为推测或示例性描述)：
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1. **文献名称**：*Bioinformatic analysis and preliminary functional characterization of C10orf46 as a novel gene involved in cardiovascular development*
**作者**：Smith J, et al.
**摘要**：通过生物信息学预测和重组蛋白表达，研究发现C10orf46在心脏发育中可能参与心肌细胞分化，与TGF-β通路存在潜在关联。
2. **文献名称**：*Expression and purification of recombinant human C10orf46 and its potential interaction with MAPK signaling pathway*
**作者**：Li X, Wang Y.
**摘要**：利用大肠杆菌系统高效表达纯化重组C10orf46.并通过质谱分析发现其可能与MAPK通路蛋白相互作用，提示其在细胞增殖中的作用。
3. **文献名称**：*C10orf46 is a novel target of p53 and regulates cell cycle progression in human cancer cells*
**作者**：Chen L, et al.
**摘要**：研究证实C10orf46受p53转录调控，重组蛋白过表达导致癌细胞周期G1期阻滞，表明其潜在抑癌功能。
4. **文献名称**：*Structural characterization of the human C10orf46 protein using NMR spectroscopy*
**作者**：Kumar A, et al.
**摘要**：首次解析重组C10orf46的核磁共振结构，揭示其含有保守的α-螺旋结构域，提示可能的核酸结合或蛋白互作能力。
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**备注**：上述文献为示例性内容，实际研究中该蛋白的文献较少，建议通过 **PubMed** 或 **UniProt**(检索号：Q8N4V2)获取最新进展。如需具体文献，可进一步限定研究领域(如肿瘤、发育生物学)。
C10orf46. also known as chromosome 10 open reading frame 46. is a poorly characterized human protein encoded by the C10orf46 gene located on the long arm (q) of chromosome 10. Despite its identification through genomic sequencing, limited experimental data exist regarding its structure, function, or biological significance. Bioinformatics analyses suggest it may encode a small protein (~20 kDa) with potential intrinsically disordered regions, though no conserved domains or motifs have been definitively identified.
Its expression appears tissue-specific, with low mRNA levels detected in most tissues, though slightly elevated in the brain, testes, and certain cancers, hinting at possible roles in cellular differentiation or oncogenesis. A few studies have linked C10orf46 to pathways involving cell cycle regulation and apoptosis via co-expression networks, but these associations remain unvalidated. Recombinant C10orf46 is typically produced in prokaryotic or eukaryotic systems for antibody generation, interaction studies, or structural analysis. However, challenges persist in characterizing its physicochemical properties and subcellular localization.
As an uncharacterized protein, C10orf46 represents a gap in the human proteome landscape. Its exploration could uncover novel biological mechanisms or therapeutic targets, aligning with growing interest in understudied proteins. Current research focuses on validating interactors, mapping post-translational modifications, and clarifying its role in health and disease.
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