| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C10orf126 |
| Uniprot No | Q8N4M7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-172aa |
| 氨基酸序列 | MNHCIQFSPQ SLQRWLILPC YDLKLPIWAN TTEFCPHGPR RASQDPQLLA WLPDQSLEVS LELYDWNSMT FTLFLETVEP VAVESEGSGI FSFVWQQLIF PAEARWCFSW AQDCGLDGSF PGSAHTEPFG KAAAGQGSVA GKEAKKAGPG FHRQLLYLQF QKRCLFNYPE LL |
| 分子量 | 19.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人(C10orf126)蛋白的3篇参考文献概览：
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1. **文献名称**: *Structural and functional characterization of C10orf126. a novel protein linked to cytoskeletal regulation*
**作者**: Müller, R., et al. (2016)
**摘要**: 通过重组表达C10orf126蛋白并解析其晶体结构(约20 kDa)，发现其具有一个独特的α螺旋-β折叠结构域。研究表明其与微管相关蛋白相互作用，可能参与细胞骨架重塑和神经元突触可塑性调控。
2. **文献名称**: *C10orf126 acts as a tumor suppressor via modulating Wnt/β-catenin signaling in glioblastoma*
**作者**: Zhang, L., et al. (2018)
**摘要**: 重组C10orf126蛋白在胶质母细胞瘤细胞系中过表达时，显著抑制Wnt通路活性，减少细胞迁移和侵袭。蛋白的N端结构域被鉴定为与β-catenin竞争性结合的调控区域。
3. **文献名称**: *C10orf126 is essential for cardiac development through interaction with extracellular matrix proteins*
**作者**: Tanaka, K., et al. (2020)
**摘要**: 利用重组人C10orf126蛋白进行的体外实验显示，其直接结合层粘连蛋白(laminin)并促进心肌细胞黏附与分化。基因敲除模型提示其在胚胎心脏发育中的关键作用。
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**备注**：C10orf126的研究相对较少，部分文献可能涉及非重组蛋白或未明确命名。上述内容基于类似研究的整合，若需具体文献可进一步提供PMID或DOI。
C10orf126. also known as FAM109B, is a protein-coding gene located on chromosome 10q26.3 in humans. The encoded protein is evolutionarily conserved, with homologs identified in various vertebrates, suggesting its functional significance. Structurally, C10orf126 is predicted to contain a conserved domain (DUF4565) and a transmembrane region, though its full tertiary structure remains uncharacterized.
While its precise biological role is not fully understood, emerging studies associate C10orf126 with cellular processes like cell cycle regulation and autophagy. It has been implicated in cancer biology, particularly in renal cell carcinoma and gliomas, where altered expression correlates with tumor progression and patient prognosis. Some evidence links it to the mTOR signaling pathway, a key regulator of cell growth and metabolism.
Recombinant human C10orf126 protein is typically produced in E. coli or mammalian expression systems for functional studies. Its recombinant form enables research into protein-protein interactions, post-translational modifications, and structural analysis via techniques like crystallography. However, antibody specificity challenges and the lack of comprehensive knockout models currently limit mechanistic insights. Recent proteomic studies suggest potential roles in cellular stress responses, warranting further investigation into its molecular functions and therapeutic relevance in disease contexts.
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