Rabbit Polyclonal HMG-1(Acetyl-Lys12) Antibody

The HMG-1 (Acetyl-Lys12) antibody is a specialized tool used to detect acetylation of lysine 12 (K12) on High Mobility Group Box 1 (HMGB1), a non-histone chromosomal protein involved in DNA organization, transcription regulation, and inflammatory signaling. HMGB1. also known as HMG-1. is a member of the HMG protein family characterized by its DNA-binding "HMG-box" domains. Post-translational modifications, such as acetylation, play a critical role in regulating HMGB1's subcellular localization and function. Acetylation at K12 is associated with nuclear-to-cytoplasmic translocation, enabling HMGB1 to act as a damage-associated molecular pattern (DAMP) molecule when released extracellularly during cell stress, necrosis, or inflammation. This modification is tightly linked to pathological processes, including sepsis, autoimmune diseases, and cancer metastasis. The HMG-1 (Acetyl-Lys12) antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study HMGB1 acetylation dynamics in cellular stress responses, epigenetic regulation, and disease mechanisms. Its specificity for the acetylated K12 epitope makes it valuable for distinguishing between acetylated and non-acetylated HMGB1 isoforms, aiding research on inflammation-driven pathologies and potential therapeutic targeting of HMGB1 pathways.