Rabbit Polyclonal ZNRF2 Antibody

The ZNRF2 (Zinc and Ring Finger Protein 2) antibody is a tool used to detect and study ZNRF2. an E3 ubiquitin ligase involved in regulating membrane protein turnover. ZNRF2. along with its homolog ZNRF1. modulates receptor degradation by tagging them with ubiquitin, targeting them for lysosomal or proteasomal degradation. It plays a role in pathways such as Wnt signaling by controlling receptor stability, impacting cellular processes like development, tissue homeostasis, and cancer progression. The antibody is critical for identifying ZNRF2 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Research highlights ZNRF2's distinct roles from ZNRF1. including its interaction with R-spondin (RSPO) proteins and potential involvement in diseases like neurodegenerative disorders or cancers. Studies using ZNRF2 antibodies have revealed its subcellular localization, tissue-specific expression patterns, and regulatory mechanisms, aiding in understanding its physiological and pathological functions. Reliable antibodies are essential for exploring ZNRF2's impact on signaling pathways and its therapeutic potential as a drug target.