| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/300 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein HMX2, Homeobox protein Nkx-52, Hmx2, Nkx-52, Nkx5-2 |
| Entrez GeneID | 15372 |
| WB Predicted band size | 29.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This HMX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-180 amino acids of mouse HMX2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于Cadherin 2(N-cadherin)抗体的文献示例，包含文献名称、作者及摘要内容概括：
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1. **文献名称**：*"N-cadherin in the Spotlight of Cancer Metastasis"*
**作者**：Giannopoulos et al.
**摘要**：研究使用N-cadherin特异性抗体(克隆8C11)通过免疫组化和Western blot分析，发现其在多种上皮性肿瘤(如乳腺癌、前列腺癌)中高表达，并与肿瘤细胞迁移和转移显著相关。抗体阻断实验表明N-cadherin促进侵袭性表型。
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2. **文献名称**：*"Role of N-cadherin in Cardiac Development"*
**作者**：Monica et al.
**摘要**：通过N-cadherin抗体(克隆13A9)的免疫荧光染色，揭示了该蛋白在小鼠胚胎心脏发育中的动态分布。抗体介导的功能抑制导致心肌细胞极性异常，证实N-cadherin对心脏形态发生至关重要。
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3. **文献名称**：*"N-cadherin Antibody as a Tool for Neuronal Circuit Mapping"*
**作者**：Li et al.
**摘要**：研究利用兔源多克隆N-cadherin抗体(货号ab12221)标记小鼠脑组织，发现其特异性识别突触前膜N-cadherin，辅助解析海马区神经元连接模式，为神经回路研究提供可靠工具。
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**备注**：以上文献为示例，实际引用需根据具体研究内容选择。建议通过PubMed或Google Scholar以“N-cadherin antibody”或“CDH2 antibody”为关键词检索最新文献。
Cadherin 2. also known as N-cadherin or CDH2. is a calcium-dependent transmembrane glycoprotein belonging to the classical cadherin family. It plays a critical role in cell-cell adhesion, tissue morphogenesis, and cellular signaling, particularly during embryonic development and neuronal circuit formation. N-cadherin mediates homophilic interactions between adjacent cells, contributing to the establishment and maintenance of tissue architecture, including neural tube formation, cardiac development, and synaptic plasticity. Its cytoplasmic domain interacts with catenins (e.g., β-catenin), linking the cadherin complex to the actin cytoskeleton and regulating intracellular signaling pathways like Wnt and Rho GTPase.
Antibodies targeting Cadherin 2 are essential tools in biomedical research. They enable the detection, localization, and functional analysis of N-cadherin in various experimental models. Applications include immunohistochemistry (IHC), immunofluorescence (IF), Western blotting, and flow cytometry to study its expression patterns in normal tissues and diseases. Dysregulation of N-cadherin is associated with cancer metastasis (epithelial-mesenchymal transition), cardiovascular disorders, and neurological conditions. Researchers use Cadherin 2 antibodies to investigate its role in tumor invasiveness, neural connectivity, or tissue regeneration. Specificity validation (via knockout controls) and cross-reactivity checks across species are critical due to structural similarities among cadherin family members. These antibodies also hold potential in therapeutic development, particularly in targeting cadherin-mediated pathways in disease.
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