Rabbit Polyclonal Alpha-1DAdrenergicReceptor Antibody

The alpha-1D adrenergic receptor (α1D-AR) is a G protein-coupled receptor (GPCR) primarily activated by catecholamines like norepinephrine and epinephrine. It plays a critical role in regulating vascular smooth muscle contraction, blood pressure, and urinary bladder function. The α1D-AR subtype is one of three α1-AR isoforms (α1A, α1B, α1D) with distinct tissue distributions and signaling pathways. While less abundantly expressed than α1A-AR and α1B-AR, α1D-AR is notably present in systemic arteries, the heart, and the central nervous system. Antibodies targeting α1D-AR are essential tools for studying its expression patterns, cellular localization, and functional roles in physiological or pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate receptor dysregulation in conditions like hypertension, benign prostatic hyperplasia, and cardiovascular remodeling. Specificity validation remains crucial due to high sequence homology among α1-AR subtypes. Recent studies also explore α1D-AR's involvement in neuroinflammatory processes and cancer progression, expanding its therapeutic relevance. Commercial α1D-AR antibodies are typically raised against unique extracellular or intracellular epitopes, often validated using knockout controls or siRNA-mediated silencing to confirm target selectivity.