Rabbit Polyclonal CHST9 Antibody

The CHST9 antibody targets the carbohydrate sulfotransferase 9 (CHST9), a member of the sulfotransferase family involved in catalyzing the transfer of sulfate groups to carbohydrate moieties. CHST9 plays a critical role in modifying glycosaminoglycans (GAGs) and glycoproteins, influencing cell-cell interactions, signaling, and extracellular matrix organization. It is particularly noted for its role in sulfating chondroitin and keratan sulfate chains, which are essential for tissue development, immune response modulation, and neuronal plasticity. CHST9 is expressed in specific tissues, including the brain, reproductive organs, and certain epithelial cells, suggesting tissue-specific functions. Dysregulation of CHST9 has been linked to pathologies such as cancer, inflammatory disorders, and reproductive system abnormalities. The CHST9 antibody is a vital tool for studying its expression patterns, subcellular localization, and molecular interactions. Researchers use it in applications like Western blotting, immunohistochemistry, and immunofluorescence to explore CHST9's involvement in cellular processes and disease mechanisms. Its development often involves immunizing host organisms with purified CHST9 protein or peptide fragments, followed by validation for specificity and sensitivity. Understanding CHST9's biological roles through antibody-based assays may contribute to therapeutic strategies targeting sulfation-dependent pathways.