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Rabbit Polyclonal VPS72 Antibody

  • 中文名： VPS72抗体
  • 别    名： TCFL1; YL1; Vacuolar protein sorting-associated protein 72 homolog; Protein YL-1; Transcription factor-like 1
货号: IPDX43682
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/100-1/300 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTCFL1; YL1; Vacuolar protein sorting-associated protein 72 homolog; Protein YL-1; Transcription factor-like 1
Entrez GeneID6944;
WB Predicted band size41kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenKLH-conjugated synthetic peptide encompassing a sequence within the center region of human VPS72.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于VPS72抗体的示例参考文献(内容为模拟生成，实际文献需通过学术数据库验证)：

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1. **文献名称**: *VPS72/Hrp1 is essential for chromatin remodeling and transcriptional activation in hematopoietic stem cells*

**作者**: Smith J, et al.

**摘要**: 本研究利用VPS72抗体进行ChIP-seq和免疫荧光分析，发现VPS72通过调控组蛋白H2B乙酰化维持造血干细胞的自我更新能力，其缺失导致白血病相关基因异常表达。

2. **文献名称**: *Structural and functional characterization of the VPS72 subunit in the SAGA complex*

**作者**: Tanaka K, et al.

**摘要**: 通过VPS72抗体的Western blot和免疫共沉淀实验，揭示了VPS72在SAGA复合体中的结构作用，证明其通过与TAF14互作调控基因转录起始。

3. **文献名称**: *VPS72 depletion disrupts endosomal trafficking and promotes cellular senescence*

**作者**: Lee S, et al.

**摘要**: 利用VPS72抗体进行亚细胞定位研究，发现VPS72缺失导致内体分选异常，激活p53通路并诱导细胞衰老，提示其在膜运输中的非经典功能。

4. **文献名称**: *Epigenetic regulation by VPS72 in colorectal cancer progression*

**作者**: Chen L, et al.

**摘要**: 通过免疫组化分析(VPS72抗体)发现，结直肠癌中VPS72表达上调与患者预后不良相关，其通过促进Wnt通路基因的染色质开放驱动肿瘤侵袭。

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**说明**：

- VPS72(又名Hrp1)常作为组蛋白伴侣蛋白参与染色质重塑，相关研究多聚焦于基因调控及疾病机制。

- 实际研究中，VPS72抗体可能用于蛋白质定位(免疫荧光)、定量(Western blot)或互作分析(Co-IP/ChIP-seq)。

- 建议通过PubMed或Google Scholar以“VPS72 antibody” + “chromatin”/“cancer”等关键词检索最新文献。

背景信息

The VPS72 antibody targets the VPS72 protein, also known as Vacuolar Protein Sorting-associated protein 72 or YL-1. a conserved subunit of the histone chaperone complex FACT (Facilitates Chromatin Transcription). FACT plays a critical role in chromatin remodeling, DNA replication, and transcriptional regulation by stabilizing nucleosomes during transcription and replication. VPS72 specifically interacts with the histone H2A-H2B dimer, aiding in their deposition or removal during chromatin reorganization. Antibodies against VPS72 are essential tools for studying its function in epigenetic regulation, gene expression, and genome stability. They are widely used in techniques like chromatin immunoprecipitation (ChIP), Western blotting, and immunofluorescence to localize VPS72 within nuclei or investigate its association with chromatin-modifying complexes. Research involving VPS72 antibodies has highlighted its role in developmental processes, stem cell differentiation, and diseases such as cancer, where FACT complex dysregulation is linked to tumor progression. These antibodies also help elucidate molecular mechanisms underlying DNA repair and replication stress responses. Given its conservation across species, VPS72 is studied in diverse model organisms, making its antibody a valuable reagent for comparative biological research. Understanding VPS72's interactions and regulation may contribute to therapeutic strategies targeting chromatin-related disorders.

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