| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/300 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4 |
| Entrez GeneID | 1137 |
| clone | 7B4H1 |
| WB Predicted band size | 70kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CHRNA4 (AA: extra 29-242) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于Cadherin 24(CDH24)抗体的3篇参考文献的简要信息：
1. **文献名称**: "Characterization of a Novel Anti-CDH24 Monoclonal Antibody for Studying Cadherin-24 Function in Neural Development"
**作者**: Smith A, et al.
**摘要**: 该研究开发并验证了一种特异性识别Cadherin-24的单克隆抗体，通过免疫印迹和免疫荧光证实其在哺乳动物神经系统中的表达，并揭示了CDH24在神经元迁移和突触形成中的作用。
2. **文献名称**: "CDH24 Expression in Colorectal Cancer: A Potential Biomarker Detected by a Polyclonal Antibody Approach"
**作者**: Lee H, et al.
**摘要**: 研究利用多克隆抗体分析CDH24在结直肠癌组织中的表达，发现其表达水平与肿瘤侵袭性和患者预后相关，提示CDH24可能作为癌症进展的生物标志物。
3. **文献名称**: "Structural Insights into Cadherin-24-Mediated Cell Adhesion Using Epitope-Specific Antibodies"
**作者**: Garcia R, et al.
**摘要**: 通过表位特异性抗体研究CDH24的细胞黏附功能，揭示其胞外结构域的关键结合区域，并证明抗体阻断可抑制细胞间黏附，为靶向治疗提供依据。
注：上述文献为示例性内容，实际研究中建议通过PubMed或Google Scholar以“CDH24 antibody”或“Cadherin-24 antibody”为关键词检索最新文献。
Cadherin-24 (CDH24), a member of the cadherin superfamily of calcium-dependent cell adhesion molecules, plays a critical role in mediating intercellular interactions and tissue morphogenesis. It is a type II classical cadherin, characterized by its extracellular cadherin repeats, a transmembrane domain, and a conserved cytoplasmic catenin-binding region. CDH24 is predominantly expressed in specific tissues, including the nervous system, where it contributes to neuronal circuit formation and synaptic plasticity. Dysregulation of CDH24 has been implicated in developmental disorders and cancer progression, particularly in processes like metastasis and epithelial-mesenchymal transition (EMT).
Antibodies targeting CDH24 are essential tools for investigating its expression, localization, and functional roles. These antibodies are typically generated using immunogenic peptides or recombinant protein fragments, with validation in assays such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They enable researchers to study CDH24's involvement in cell adhesion, signaling pathways (e.g., Wnt/β-catenin), and its potential as a biomarker in diseases like glioblastoma or colorectal cancer. Challenges in antibody development include ensuring specificity due to homology among cadherin family members. Recent studies also explore therapeutic applications, such as blocking CDH24 to inhibit invasive cancer phenotypes. Ongoing research aims to clarify its tissue-specific functions and therapeutic targeting potential.
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