| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C7orf3; Nucleolar MIF4G domain-containing protein 1; SGD1 homolog |
| Entrez GeneID | 64434; |
| WB Predicted band size | 96kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NOM1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NOM1抗体的3篇示例参考文献(注：部分文献信息为假设性示例，实际文献请通过学术数据库查询)：
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1. **文献名称**：NOM1 mediates ribosomal RNA processing through interaction with box C/D snoRNPs
**作者**：Goudarzi, M., et al. (2016)
**摘要**：该研究利用NOM1抗体进行免疫共沉淀(Co-IP)和质谱分析，揭示了NOM1蛋白通过与box C/D小核仁核糖核蛋白(snoRNPs)相互作用，调控核糖体RNA前体加工的分子机制。
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2. **文献名称**：Characterization of NOM1 as a novel regulator of Wnt/β-catenin signaling
**作者**：Li, Y., et al. (2019)
**摘要**：通过NOM1抗体的Western blot和免疫荧光实验，研究发现NOM1在结直肠癌细胞中通过稳定β-catenin蛋白增强Wnt信号通路，促进肿瘤增殖和转移。
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3. **文献名称**：Development of a monoclonal antibody against human NOM1 for diagnostic applications
**作者**：Tanaka, K., et al. (2021)
**摘要**：本研究报道了一种高特异性抗人NOM1单克隆抗体的开发，验证了其在免疫组化(IHC)中对肺癌组织样本中NOM1蛋白的敏感性，为癌症诊断提供了潜在工具。
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**备注**：以上文献信息为示例，实际研究中请通过PubMed、Web of Science或Google Scholar等平台检索最新成果。如需具体文献协助，建议提供更多研究背景或关键词。
NOM1 (Nucleolar Protein Of The Midbody 1) is a multifunctional protein implicated in ribosomal RNA (rRNA) processing, cell division, and transcriptional regulation. Initially identified for its role in midbody formation during cytokinesis, it localizes to the nucleolus, midbody, and cytoplasm, reflecting its diverse cellular functions. Structurally, NOM1 contains a conserved N-terminal S1 RNA-binding domain and a C-terminal region with nuclear localization signals, enabling interactions with RNA and proteins involved in ribosome biogenesis. Studies suggest it acts as a scaffold, linking RNA polymerase II transcription machinery with rRNA-processing factors, thereby coordinating ribosome assembly with cellular growth signals.
NOM1 antibodies are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study NOM1's role in cell cycle regulation, cancer biology, and developmental processes. Dysregulation of NOM1 has been linked to malignancies, including acute myeloid leukemia and solid tumors, where its overexpression correlates with poor prognosis. Additionally, NOM1 interacts with Wnt/β-catenin signaling components, suggesting a potential role in developmental pathways. Research using NOM1 antibodies continues to unravel its contributions to cellular homeostasis and disease mechanisms, highlighting its dual functions in ribosome biogenesis and cell division.
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