| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Afamin, Alpha-albumin, Alpha-Alb, AFM, ALB2, ALBA |
| Entrez GeneID | 173 |
| WB Predicted band size | 69.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This AFM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-76 amino acids from the N-terminal region of human AFM. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于MRPS18A抗体的3篇参考文献示例(基于真实文献改写，部分信息可能简化或调整)：
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1. **文献名称**：*Mitochondrial ribosomal protein S18A family interacts with HCV NS5B protein*
**作者**：Kim SJ et al.
**摘要**：研究通过免疫共沉淀(使用MRPS18A抗体)发现，线粒体核糖体蛋白S18A家族成员与丙型肝炎病毒NS5B蛋白相互作用，提示其在病毒复制中的潜在作用。
2. **文献名称**：*MRPS18A modulates mitochondrial translation to maintain oxidative phosphorylation in mammalian cells*
**作者**：Wang Y et al.
**摘要**：利用MRPS18A抗体进行Western blot和免疫荧光实验，发现敲低MRPS18A会破坏线粒体翻译过程，导致氧化磷酸化功能障碍，影响细胞能量代谢。
3. **文献名称**：*Proteomic analysis of mitochondrial ribosome-associated proteins in Parkinson's disease*
**作者**：Smith J et al.
**摘要**：通过抗MRPS18A抗体富集线粒体核糖体复合物，结合质谱分析，揭示了帕金森病患者中线粒体翻译机制的异常，可能与神经元退行性变相关。
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注：以上文献名称和内容为示例性质，实际引用时需核对真实来源及细节。建议通过PubMed或Google Scholar以关键词“MRPS18A antibody”或“MRPS18A mitochondrial ribosome”检索最新研究。
MRPS18A (Mitochondrial Ribosomal Protein S18A) is a component of the mitochondrial ribosome small subunit (28S), which plays a critical role in mitochondrial protein synthesis. Mitochondrial ribosomes are responsible for translating genes encoded by mitochondrial DNA (mtDNA), particularly subunits of the oxidative phosphorylation (OXPHOS) complexes essential for ATP production. MRPS18A is thus vital for maintaining mitochondrial function and cellular energy homeostasis. Dysregulation of mitochondrial ribosomal proteins, including MRPS18A, has been linked to mitochondrial disorders, cancer, and aging-related pathologies.
Antibodies targeting MRPS18A are valuable tools for studying mitochondrial biology and disease mechanisms. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess MRPS18A expression, localization, and interactions. These antibodies help investigate its role in ribosome assembly, OXPHOS complex biogenesis, and mitochondrial dynamics. In disease research, MRPS18A antibodies aid in exploring associations between mitochondrial dysfunction and conditions such as neurodegenerative diseases, cardiomyopathies, or cancer progression. Commercially available MRPS18A antibodies are typically raised in hosts like rabbits or mice, with validation across specific applications and sample types (e.g., cell lysates, tissues). Researchers must verify antibody specificity using controls like knockout cells or siRNA-mediated knockdown to ensure reliable results.
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