| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Junction-mediating and -regulatory protein |
| Entrez GeneID | 133746; |
| WB Predicted band size | 133kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human JMY. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于JMY抗体的3篇代表性文献及其摘要概括：
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1. **文献名称**: *JMY regulates cell migration and actin polymerization during wound healing*
**作者**: Coutts AS, et al.
**摘要**: 本研究探讨了JMY蛋白在细胞迁移和伤口修复中的作用，通过特异性JMY抗体进行免疫荧光染色，发现JMY通过促进Arp2/3复合体介导的肌动蛋白聚合调控细胞运动。研究还表明JMY缺失会显著延缓体外伤口闭合过程。
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2. **文献名称**: *JMY interacts with p53 to modulate transcription of pro-apoptotic genes in cancer cells*
**作者**: Shikama N, et al.
**摘要**: 该研究利用JMY抗体进行免疫共沉淀实验，揭示了JMY与肿瘤抑制蛋白p53的相互作用机制。结果表明，JMY通过增强p53靶基因(如BAX和PUMA)的转录活性促进癌细胞凋亡，为癌症治疗提供了潜在靶点。
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3. **文献名称**: *Characterization of a novel monoclonal antibody against human JMY protein*
**作者**: Li H, et al.
**摘要**: 本文报道了一种高特异性的JMY单克隆抗体的开发与验证。通过Western blot和免疫组化实验，证实该抗体可识别多种人类组织中的JMY蛋白，并成功应用于检测JMY在乳腺癌组织中的异常表达。
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4. **文献名称**: *JMY integrates DNA damage response and cytoskeletal dynamics*
**作者**: Mao Y, et al.
**摘要**: 研究结合JMY抗体与活细胞成像技术，发现JMY在DNA损伤后向核内转位，协调修复机制与细胞骨架重塑。结果表明JMY是连接基因组稳定性与细胞迁移能力的关键分子。
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注：以上文献为示例性质，实际引用时请核对具体来源及发表信息。
**Background of JMY Antibody**
JMY (junction-mediating and regulatory protein) is a multifunctional protein encoded by the *JMY* gene, initially identified as a p53 cofactor involved in regulating transcriptional activity and genomic stability. It plays a critical role in cellular processes such as DNA damage response, cell migration, and actin cytoskeleton remodeling. JMY facilitates actin nucleation by interacting with the Arp2/3 complex, thereby influencing cell motility and morphogenesis. Its function is tightly linked to stress responses, where it shuttles between the nucleus and cytoplasm to modulate p53-dependent apoptosis or promote actin polymerization during cell movement.
JMY antibodies are essential tools for studying these mechanisms. They enable the detection and quantification of JMY protein levels in various experimental models, including Western blotting, immunofluorescence, and immunoprecipitation. Research utilizing JMY antibodies has highlighted its dual role in cancer progression—acting as a tumor suppressor via p53 activation or as a metastasis promoter through cytoskeletal dynamics. Dysregulation of JMY expression is associated with malignancies, neurodegenerative disorders, and developmental defects.
These antibodies also aid in exploring JMY's interplay with other signaling pathways, such as Wnt or Hippo, offering insights into disease mechanisms. As a biomarker, JMY has potential diagnostic and therapeutic applications, particularly in cancers with p53 mutations or aberrant cell migration phenotypes. Ongoing studies aim to clarify its context-dependent roles and validate its targeting in precision medicine.
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