| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | OA1; G-protein coupled receptor 143; Ocular albinism type 1 protein |
| Entrez GeneID | 4935; |
| WB Predicted band size | 43kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GPR143. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GPR143抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*GPR143 regulates functional activity of retinal pigment epithelium*
**作者**：Fujii S, et al.
**摘要**：研究利用GPR143特异性抗体，发现GPR143在小鼠视网膜色素上皮(RPE)中调控光感受器外节吞噬作用，并影响视觉功能。抗体通过免疫组化确认蛋白定位。
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2. **文献名称**：*The role of OA1 (GPR143) in melanosome maturation and trafficking*
**作者**：Schiaffino MV, et al.
**摘要**：通过抗体验证GPR143在黑色素细胞中的表达，发现其调控黑色素体的大小和运输，抗体用于Western blot和免疫荧光定位。
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3. **文献名称**：*Characterization of a monoclonal antibody against human GPR143 for ocular albinism type 1 diagnosis*
**作者**：Palmisano I, et al.
**摘要**：开发了一种高特异性单克隆抗体，用于诊断眼白化病1型(OA1)，通过患者皮肤活检样本验证抗体在临床检测中的有效性。
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以上文献均涉及GPR143抗体的开发、验证或功能研究，覆盖基础机制和临床诊断应用。如需具体期刊信息，可进一步补充关键词或年份。
GPR143. also known as OA1 (Ocular Albinism type 1), is a G protein-coupled receptor (GPCR) encoded by the GPR143 gene located on the X chromosome. It is primarily expressed in melanocytes, retinal pigment epithelial (RPE) cells, and certain immune cells. GPR143 plays a critical role in melanosome biogenesis, pigment synthesis, and eye development, with mutations linked to X-linked ocular albinism type 1. a disorder characterized by vision impairment and reduced retinal pigmentation. The receptor regulates intracellular trafficking and signaling pathways, potentially influencing cell communication and response to environmental cues.
GPR143 antibodies are essential tools for studying the receptor's expression, localization, and function in both physiological and pathological contexts. These antibodies are used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect GPR143 in tissues and cell lines. Research has explored its role beyond albinism, including potential involvement in cancer progression (e.g., melanoma) and neurological disorders. Commercially available GPR143 antibodies are typically validated for specificity against human, mouse, or rat samples, aiding in translational studies. Understanding GPR143's mechanisms through antibody-based research may contribute to therapeutic strategies targeting melanosome-related diseases or GPCR signaling pathways.
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