Rabbit Polyclonal Frizzled1/2/7 Antibody

Frizzled 1/2/7 (FZD1/2/7) antibodies are essential tools for studying the Frizzled family of G protein-coupled receptors (GPCRs), which play critical roles in Wnt signaling pathways. FZD receptors, including FZD1. FZD2. and FZD7. act as transmembrane receptors for Wnt proteins, mediating both canonical (β-catenin-dependent) and non-canonical (β-catenin-independent) signaling. These receptors are involved in embryogenesis, tissue homeostasis, cell polarity, and proliferation. FZD1 is broadly expressed in tissues like the brain and heart, while FZD2 and FZD7 are often linked to developmental processes and cancer progression, particularly in colorectal, breast, and hepatocellular carcinomas. Antibodies targeting FZD1/2/7 enable researchers to detect protein expression, localization, and interactions in experimental models. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunocytochemistry (ICC), and flow cytometry. Due to overlapping structural homology among FZD receptors, some antibodies may exhibit cross-reactivity, necessitating careful validation. Dysregulation of FZD1/2/7 is associated with tumorigenesis, metastasis, and drug resistance, making these antibodies valuable for investigating therapeutic targets or biomarkers in cancer. Their applications extend to studying tissue regeneration, stem cell biology, and Wnt-related diseases, underscoring their importance in both basic research and translational medicine.