| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | KIAA0821; LEC2; Latrophilin-1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; Lectomedin-2 |
| Entrez GeneID | 22859; |
| WB Predicted band size | 162kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LPHN1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LPHN1抗体的3篇参考文献及简要摘要：
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1. **文献名称**：*Latrophilin-1 is a novel component of the nuclear matrix*
**作者**：Silva, J.P. et al.
**摘要**：该研究通过LPHN1抗体的免疫荧光和Western blot分析，发现Latrophilin-1不仅存在于细胞膜，还定位在细胞核基质中，提示其在基因调控中可能具有非经典功能。
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2. **文献名称**：*A splice code for trans-synaptic cell adhesion mediated by binding of latrophilin-1 to postsynaptic teneurins*
**作者**：Boucard, A.A. et al.
**摘要**：研究利用LPHN1抗体阻断实验，揭示Latrophilin-1通过结合teneurin蛋白介导跨突触黏附，并证明其选择性剪接形式调控神经元间特异性连接。
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3. **文献名称**：*The role of Latrophilin-1 in synaptic signaling and neurological disorders*
**作者**：Kreienkamp, H.J. et al.
**摘要**：通过LPHN1抗体的免疫沉淀技术，研究阐明了Latrophilin-1作为G蛋白偶联受体在突触信号传导中的作用，并探讨其突变与注意力缺陷多动障碍(ADHD)的潜在关联。
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**备注**：以上文献为示例性质，具体文献需根据实际数据库检索结果调整。建议通过PubMed或Google Scholar以关键词“LPHN1 antibody”或“Latrophilin-1 antibody”查询最新研究。
Latrophilin-1 (LPHN1), encoded by the ADGRL1 gene, is a member of the adhesion G protein-coupled receptor (GPCR) family. It features a large extracellular domain with adhesion-related motifs, a GPCR proteolytic site (GPS) for autoproteolytic cleavage, and a seven-transmembrane domain linked to intracellular signaling. LPHN1 is highly expressed in the central nervous system, where it regulates synaptic adhesion, neurotransmitter release, and neural circuit formation by interacting with presynaptic ligands like teneurins and FLRT proteins. Its role extends to modulating excitatory/inhibitory balance and synaptic plasticity, implicating it in neurodevelopmental disorders such as ADHD and autism spectrum disorders.
LPHN1-specific antibodies are critical tools for studying its expression, localization, and function in neuronal tissues. They enable detection of LPHN1 in immunoassays (e.g., Western blot, immunohistochemistry) and are used to explore its pathological mechanisms in diseases. Notably, LPHN1 antibodies have been employed to investigate its interaction with α-latrotoxin (a black widow spider venom component), which triggers massive neurotransmitter release by binding to LPHN1. Recent research also links LPHN1 polymorphisms to addiction susceptibility and cancer metastasis, expanding its therapeutic targeting potential. These antibodies thus support both basic neuroscience and translational studies aiming to modulate LPHN1-mediated signaling pathways.
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