| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 28S ribosomal protein S7 mitochondrial; MRP-S7; S7mt; bMRP-27a; bMRP27a |
| Entrez GeneID | 51081; |
| WB Predicted band size | 24kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MRPS7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及MRPS7抗体的参考文献及其摘要内容概括：
1. **文献名称**：*Mitochondrial ribosomal protein S7 is a potential biomarker for colorectal cancer progression*
**作者**：Lee, H. et al.
**摘要**：研究通过Western blot和免疫组化分析MRPS7在结直肠癌组织中的表达，发现其高表达与肿瘤转移和不良预后相关，提示MRPS7可能作为癌症进展的潜在标志物。
2. **文献名称**：*MRPS7 mutations linked to impaired mitochondrial translation cause developmental disorders*
**作者**：Smith, R. et al.
**摘要**：利用MRPS7抗体检测患者细胞系中的蛋白表达，发现特定突变导致MRPS7稳定性下降，进而影响线粒体蛋白质合成，与儿童神经发育异常相关。
3. **文献名称**：*Functional characterization of MRPS7 in mitochondrial ribosome assembly*
**作者**：Gomez-Duran, A. & Chinnery, P.F.
**摘要**：通过siRNA敲低MRPS7并结合免疫荧光技术，证明MRPS7对线粒体核糖体小亚基的组装至关重要，其缺失导致氧化磷酸化功能受损。
4. **文献名称**：*Antibody-based profiling of mitochondrial ribosome composition across species*
**作者**：Miller, C. et al.
**摘要**：开发并验证了一种高特异性MRPS7抗体，用于比较不同物种线粒体核糖体蛋白组成，揭示了进化中核糖体结构的保守性和差异性。
注：以上文献名为虚拟示例，实际引用需根据具体研究检索。建议通过PubMed或Web of Science以“MRPS7 antibody”或“MRPS7 mitochondrial ribosome”为关键词获取真实文献。
The mitochondrial ribosomal protein S7 (MRPS7) is a key component of the small subunit (28S) of the mitochondrial ribosome (mitoribosome), which is essential for translating mitochondrial DNA (mtDNA)-encoded proteins involved in oxidative phosphorylation (OXPHOS). As mitochondria rely on their own translation machinery to produce core subunits of the electron transport chain complexes, MRPS7 plays a critical role in maintaining cellular energy metabolism. MRPS7 antibodies are widely used tools in mitochondrial research to investigate ribosome assembly, mitochondrial protein synthesis, and their dysregulation in diseases.
These antibodies enable the detection and quantification of MRPS7 in various experimental models, including Western blotting, immunofluorescence, and immunohistochemistry. They are particularly valuable in studying mitochondrial disorders linked to mutations in mitoribosomal proteins, such as encephalopathies, cardiomyopathies, or growth deficiencies. Additionally, MRPS7 antibodies help explore the role of mitochondrial dysfunction in cancer, neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s), and aging, where altered OXPHOS activity is a hallmark.
Commercial MRPS7 antibodies are typically raised against conserved peptide sequences, with validation in knockout models or siRNA-treated cells to confirm specificity. Researchers also utilize these antibodies to assess tissue-specific expression patterns or subcellular localization, aiding in the mechanistic understanding of mitochondrial translation defects. Overall, MRPS7 antibodies serve as critical reagents for advancing studies on mitochondrial biology and associated pathologies.
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