| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BMRP; MRPL27; RPML27; 39S ribosomal protein L41, mitochondrial; L41mt; MRP-L41; 39S ribosomal protein L27 homolog; Bcl-2-interacting mitochondrial ribosomal protein L41; Cell proliferation-inducing gene 3 protein; MRP-L27 homolog |
| Entrez GeneID | 64975; |
| WB Predicted band size | 21kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MRPL41. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MRPL41抗体的3篇参考文献的简要概括：
1. **《MRPL41 regulates mitochondrial apoptosis by targeting p53》**
- 作者：Zhang Y. et al.
- 摘要：该研究通过Western blot和免疫荧光技术，利用MRPL41抗体验证其在细胞中的定位及表达水平，发现MRPL41通过结合p53调控线粒体依赖性细胞凋亡。
2. **《Mitochondrial ribosomal protein L41 suppresses cell growth in hepatocellular carcinoma》**
- 作者：Chen L. et al.
- 摘要：研究使用MRPL41抗体分析肝癌组织中该蛋白的表达，发现其低表达与肿瘤进展相关，并通过抑制mTOR通路阻碍癌细胞增殖。
3. **《Characterization of a polyclonal antibody against human MRPL41 for mitochondrial proteomics》**
- 作者：Kim S. et al.
- 摘要：文献描述了一种兔源多克隆抗体的制备与验证，证实该抗体可特异性识别内源性MRPL41.适用于线粒体蛋白质组学研究。
(注：上述文献为示例性质，实际引用需根据具体研究补充。)
The mitochondrial ribosomal protein L41 (MRPL41) is a component of the large subunit of the mitochondrial ribosome, essential for mitochondrial protein synthesis and oxidative phosphorylation. Encoded by nuclear DNA, MRPL41 is imported into mitochondria, where it contributes to the assembly and stability of the ribosome machinery required for translating mitochondrially encoded genes. Beyond its ribosomal role, MRPL41 has been implicated in apoptosis regulation and cellular stress responses. Studies suggest it interacts with pro-apoptotic proteins like Bcl-2 family members and modulates p53-dependent pathways, linking mitochondrial function to cell fate decisions.
Antibodies targeting MRPL41 are valuable tools for investigating mitochondrial biology, protein localization, and expression dynamics under physiological or pathological conditions. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to assess MRPL41 levels in tissues or cultured cells. Dysregulation of MRPL41 has been observed in cancers, metabolic disorders, and neurodegenerative diseases, highlighting its potential as a biomarker or therapeutic target. Researchers also employ these antibodies to explore MRPL41's dual roles in energy metabolism and apoptosis, particularly in contexts like tumorigenesis, ischemia-reperfusion injury, and mitochondrial dysfunction-related pathologies. Species specificity (e.g., human, mouse) and validation in relevant experimental models are critical considerations for their application.
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