Rabbit Polyclonal KDELR3 Antibody

The KDEL receptor 3 (KDELR3) is a member of the KDEL receptor family, which plays a critical role in the retrieval of endoplasmic reticulum (ER)-resident proteins that escape to the Golgi apparatus. These receptors recognize proteins with a C-terminal KDEL (Lys-Asp-Glu-Leu) or related motif, facilitating their retrograde transport back to the ER via COPI-coated vesicles. KDELR3. encoded by the *KDELR3* gene in humans, is one of three paralogs (KDELR1-3) sharing structural homology but exhibiting distinct tissue expression patterns and functional roles. It is a seven-transmembrane domain protein localized primarily to the Golgi, where it modulates ER protein homeostasis and stress responses. Dysregulation of KDELR3 has been implicated in pathological conditions, including cancer progression, neurodegenerative diseases, and immune disorders, due to its influence on secretory pathway dynamics, unfolded protein response (UPR), and cell survival. Antibodies targeting KDELR3 are essential tools for studying its expression, localization, and interaction networks. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate KDELR3's role in cellular physiology and disease mechanisms. Validated antibodies typically demonstrate specificity for KDELR3 over other family members, enabling precise detection in diverse experimental models. Research utilizing KDELR3 antibodies continues to uncover its therapeutic potential as a biomarker or drug target.