| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TM7SF1L2; Integral membrane protein GPR137C; Transmembrane 7 superfamily member 1-like 2 protein |
| Entrez GeneID | 283554; |
| WB Predicted band size | 47kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GPR137C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GPR137C抗体的3篇示例参考文献(内容为虚构示例，仅供参考格式)：
1. **文献名称**：*GPR137C as a Novel Biomarker in Hepatocellular Carcinoma: Antibody Development and Clinical Validation*
**作者**：Smith J, et al.
**摘要**：本研究开发了一种高特异性抗GPR137C单克隆抗体，通过免疫组化分析发现GPR137C在肝癌组织中显著高表达，且与患者预后不良相关，提示其作为肝癌诊断标志物的潜力。
2. **文献名称**：*Functional Characterization of GPR137C in Prostate Cancer Using Targeted Antibodies*
**作者**：Zhang L, et al.
**摘要**：通过抗GPR137C抗体的Western blot和流式细胞术分析，揭示了GPR137C在前列腺癌细胞中的促增殖作用，并证实其通过激活mTOR信号通路驱动肿瘤生长。
3. **文献名称**：*GPR137C Antibody-Based Screening Identifies Its Role in Cell Cycle Regulation*
**作者**：Lee S, et al.
**摘要**：利用抗GPR137C抗体的免疫荧光技术，发现该蛋白在细胞周期G1/S期转换中起调控作用，沉默GPR137C可诱导细胞周期停滞，为靶向治疗提供新思路。
4. **文献名称**：*Development of a Polyclonal Antibody Against GPR137C and Its Application in Cancer Cell Lines*
**作者**：Chen R, et al.
**摘要**：报道了一种兔源多克隆抗体的制备方法，验证其在结肠癌和乳腺癌细胞系中的特异性，并发现GPR137C高表达与癌细胞侵袭性增强相关。
(注：以上文献为模拟内容，实际引用需检索真实数据库如PubMed、Web of Science等。)
GPR137C (G Protein-Coupled Receptor 137C) is an orphan receptor belonging to the G protein-coupled receptor (GPCR) family, a large group of membrane proteins involved in signal transduction. Despite its classification, the endogenous ligand, precise signaling mechanisms, and physiological roles of GPR137C remain poorly characterized. It is encoded by the *GPR137C* gene, located on human chromosome 14q24.2. and is evolutionarily conserved across species, suggesting potential functional significance.
Research has linked GPR137C to various cancers, including prostate, liver, and colorectal cancers, where its overexpression correlates with tumor progression, metastasis, and poor prognosis. It is hypothesized to regulate cell proliferation, apoptosis, or metabolic pathways, though exact mechanisms are under investigation. Antibodies targeting GPR137C have become essential tools for elucidating its expression patterns, subcellular localization, and interactions. These antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, aiding in both basic research and clinical studies.
Current efforts focus on clarifying GPR137C's role in disease and exploring its potential as a diagnostic biomarker or therapeutic target. Challenges include resolving its structural biology and signaling context, which could unlock novel GPCR-mediated pathways in health and disease.
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