Rabbit Polyclonal CLIP3 Antibody

The CLIP3 antibody targets the cytoplasmic linker protein 3 (CLIP3), also known as CLIP-170-related protein (CLIP-R), a member of the cytoplasmic linker protein family. CLIP3 is involved in intracellular membrane trafficking, organelle dynamics, and microtubule-mediated transport processes. It interacts with microtubules and endosomal compartments, playing roles in vesicle formation, cargo sorting, and maintaining Golgi apparatus integrity. Structurally, CLIP3 contains N-terminal CAP-Gly domains for microtubule binding and a C-terminal coiled-coil region mediating dimerization. Its function intersects with signaling pathways, including EGFR trafficking and Wnt/β-catenin regulation. Dysregulation of CLIP3 has been implicated in cancer progression, neurological disorders, and viral infection mechanisms. Antibodies against CLIP3 are essential tools for studying its expression, localization, and interactions in cellular models. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore CLIP3's role in membrane dynamics, disease pathogenesis, and therapeutic targeting. Research utilizing CLIP3 antibodies has provided insights into its tumor-suppressive or oncogenic roles, depending on context, highlighting its potential as a biomarker or therapeutic target in malignancies.