| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gamma-aminobutyric acid receptor subunit gamma-1; GABA(A) receptor subunit gamma-1 |
| Entrez GeneID | 2565; |
| WB Predicted band size | 54kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GABRG1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于领域知识的模拟参考文献(非真实文献，仅供格式参考)：
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1. **"GABRG1 antibody characterization in mammalian brain tissue"**
*Author: Smith J, et al.*
摘要：该研究验证了兔源多克隆GABRG1抗体的特异性，通过免疫印迹和免疫组化确认其在啮齿类及人类脑组织中的结合能力，发现GABRG1主要分布于海马及皮层抑制性突触。
2. **"GABRG1 subunit deficiency alters inhibitory neurotransmission in mice"**
*Author: Tanaka K, et al.*
摘要：利用GABRG1抗体检测基因敲除小鼠模型，发现GABRG1缺失导致GABA能传递减弱，并诱发焦虑样行为，提示其与情绪障碍的潜在关联。
3. **"Structural mapping of GABRG1-containing receptors using cryo-EM"**
*Author: Chen L, et al.*
摘要：结合特异性抗体分离天然GABA_A受体复合体，通过冷冻电镜解析含GABRG1亚基的受体三维结构，揭示其参与配体门控通道调控的分子机制。
4. **"GABRG1 expression in epilepsy-associated focal cortical dysplasia"**
*Author: Wang H, et al.*
摘要：采用免疫组化分析癫痫患者脑组织，发现GABRG1抗体标记的神经元表达显著下调，提示其表达异常可能导致局部神经网络过度兴奋。
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建议通过PubMed或Google Scholar搜索**“GABRG1 antibody” + “application”**或**“GABRG1 receptor function”**获取真实文献。如需具体文献协助，请进一步说明需求。
The GABRG1 antibody is a research tool designed to detect the gamma-1 subunit (γ1) of the γ-aminobutyric acid type A (GABA-A) receptor, a ligand-gated ion channel critical for inhibitory neurotransmission in the central nervous system. GABA-A receptors are pentameric complexes composed of various subunit combinations (α, β, γ, δ, etc.), with the γ1 subunit encoded by the *GABRG1* gene. Unlike the more widely studied γ2 subunit, γ1 has limited expression, primarily found in specific brain regions (e.g., thalamus, hypothalamus) and peripheral tissues. GABRG1 antibodies are typically polyclonal or monoclonal, validated for applications like Western blotting, immunohistochemistry, or immunofluorescence to study receptor localization, expression patterns, and functional roles.
Research involving GABRG1 antibodies has explored its potential involvement in neurological disorders. While mutations in other GABA-A subunits (e.g., GABRG2) are linked to epilepsy and sleep disorders, GABRG1's pathophysiological role remains less defined. Some studies suggest altered γ1 expression in neurodevelopmental conditions or cancer, though findings are preliminary. These antibodies also aid in investigating receptor assembly and pharmacology, as γ subunits influence receptor sensitivity to benzodiazepines and other modulators. However, cross-reactivity with related subunits and tissue-specific variability require careful experimental validation. Overall, GABRG1 antibodies serve as essential tools for dissecting the diversity of GABA-A receptors and their contributions to health and disease.
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