| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gamma-aminobutyric acid receptor subunit delta; GABA(A) receptor subunit delta |
| Entrez GeneID | 2563; |
| WB Predicted band size | 51kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GABRD. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇关于GABRD抗体的研究文献概览(模拟数据，仅供参考)：
---
1. **《GABRD receptor expression in temporal lobe epilepsy》**
*作者：Smith A et al. (2020)*
摘要：使用特异性GABRD抗体检测癫痫患者脑组织中δ亚基的分布变化，发现海马区表达量显著降低，提示其与癫痫发作阈值相关。
2. **《Alcohol dependence alters GABA-A δ subunit levels in prefrontal cortex》**
*作者：Chen L & Roberts M (2018)*
摘要：通过免疫组化结合GABRD抗体，发现酒精依赖小鼠前额叶皮层δ亚基表达下调，可能与抑制性神经传递功能损伤有关。
3. **《Developmental regulation of GABAA receptor δ subunit in murine brain》**
*作者：Park J et al. (2016)*
摘要：利用GABRD抗体追踪小鼠大脑发育过程，发现δ亚基在成年期特异性富集于丘脑和齿状回，提示其在神经可塑性中的年龄依赖性作用。
---
注：以上为示例性内容，实际文献需通过PubMed或Web of Science等平台检索关键词“GABRD antibody”或“GABA-A receptor delta subunit”获取。建议使用抗体生产商(如Alomone Labs、Abcam)的技术手册引用原始研究。
The GABRD antibody is a research tool targeting the delta subunit of the γ-aminobutyric acid type A (GABA-A) receptor, a ligand-gated chloride channel critical for inhibitory neurotransmission in the central nervous system. The GABRD subunit forms part of extrasynaptic GABA-A receptors, which mediate tonic inhibition and regulate neuronal excitability. Unlike more common GABA-A subunits (e.g., α1. β2), GABRD expression is region-specific, predominantly localized in the thalamus, hippocampus, and cerebellum. Its unique pharmacological properties and role in modulating neurosteroid sensitivity make it a focus in studies of neurological and psychiatric disorders.
GABRD antibodies are widely used in immunohistochemistry, western blotting, and immunofluorescence to map receptor distribution, assess protein expression changes in disease models, and validate gene-editing outcomes. Research links GABRD dysfunction to epilepsy, sleep disorders, and mood abnormalities. For example, GABRD mutations are associated with idiopathic generalized epilepsy and enhanced anxiety-like behaviors in animal studies. Antibodies against GABRD also aid in exploring neurosteroid interactions, as δ-containing receptors bind endogenous modulators like allopregnanolone. Commercial GABRD antibodies are typically raised in rabbits or mice using peptide antigens from conserved regions of the human or rodent protein. Validation includes knockout controls and tissue-specific expression profiling to ensure specificity.
×
