Rabbit Polyclonal CEP78 Antibody

CEP78 (Centrosomal Protein 78) is a key component of the centrosome, a microtubule-organizing center critical for cell division, cytoskeletal organization, and cilia formation. It plays a role in maintaining centrosome structure, regulating centriole duplication, and ensuring proper mitotic spindle assembly. Mutations in the CEP78 gene are linked to human diseases, including autosomal recessive cone-rod dystrophy with hearing loss, highlighting its importance in retinal and auditory function. CEP78 antibodies are essential tools for studying these processes, enabling researchers to visualize protein localization via immunofluorescence, assess expression levels through Western blotting, or investigate interactions in co-immunoprecipitation assays. These antibodies are typically generated in hosts like rabbits or mice, targeting specific epitopes of human CEP78. Their applications extend to exploring disease mechanisms, particularly in ciliopathies and degenerative disorders, where disrupted centrosomal function may contribute to pathology. Recent studies also suggest potential roles in cancer biology, as centrosome abnormalities are common in tumors. By facilitating precise detection of CEP78 in cellular and tissue models, these antibodies support advances in understanding cell cycle regulation, cilia-related diseases, and therapeutic target identification.