| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MIB1 DIP1 KIAA1323 ZZANK2 |
| Entrez GeneID | 57534; |
| WB Predicted band size | 130kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide from human protein at AA range: 901-950 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于MIB1抗体的3篇示例参考文献(内容为虚构示例，仅供参考)：
1. **文献名称**：*MIB1 Proliferation Index as a Prognostic Marker in Breast Cancer*
**作者**：Smith A, et al.
**摘要**：研究MIB1抗体检测的增殖指数与乳腺癌患者预后的相关性，发现高MIB1指数与肿瘤侵袭性和较低生存率显著相关。
2. **文献名称**：*Comparative Analysis of MIB1 and Ki-67 in Glioblastoma Diagnosis*
**作者**：Lee C, et al.
**摘要**：比较MIB1抗体与Ki-67抗体在神经胶质瘤诊断中的一致性，证实MIB1可作为评估肿瘤细胞增殖活性的可靠替代标志物。
3. **文献名称**：*MIB1 Expression in Cutaneous Melanoma: Correlation with Metastatic Potential*
**作者**：Garcia R, et al.
**摘要**：探讨皮肤黑色素瘤中MIB1标记的增殖活性与转移风险的关系，提出MIB1指数可辅助临床分期决策。
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如需真实文献，建议通过PubMed(https://pubmed.ncbi.nlm.nih.gov)或Google Scholar检索关键词“MIB1 antibody”、“Ki-67 proliferation marker”等。
The MIB1 antibody is a monoclonal antibody widely used in immunohistochemistry to detect the Ki-67 antigen, a nuclear protein expressed in actively proliferating cells during all phases of the cell cycle (G1. S, G2. M) except the resting phase (G0). Ki-67 is a marker of cellular proliferation, making MIB1 a critical tool in assessing tumor growth fraction in cancer pathology. The antibody, raised against recombinant parts of the Ki-67 protein, is named after its clone designation (MIB-1) and is effective in formalin-fixed, paraffin-embedded tissues, enabling routine clinical use.
Originally identified in the 1980s, Ki-67's role in cell cycle regulation remains incompletely understood, but its expression correlates strongly with mitotic activity. MIB1 staining is routinely employed to determine proliferation indices in tumors, aiding in grading malignancies (e.g., gliomas, lymphomas, breast cancers), predicting prognosis, and evaluating response to therapy. High Ki-67 indices often associate with aggressive tumor behavior and poorer outcomes.
While alternative proliferation markers exist (e.g., PCNA), MIB1's reliability and specificity in archival tissues have solidified its role in diagnostic pathology. However, interpretation requires standardization due to variability in staining protocols and scoring methods. Beyond oncology, MIB1 is utilized in research on tissue regeneration, stem cells, and developmental biology. Its clinical and research utility underscores its importance as a biomarker for cellular proliferation dynamics.
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