关键信息
-
基因名
SLC2A9
- 应用
-
别名
SLC2A9；GLUT9；Solute carrier family 2. facilitated glucose transporter member 9
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9NRM0
-
表达区间
1-540aa
-
氨基酸序列
MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP
-
分子量
60.2 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
SLC2A9, a member of the solute carrier family of transporters, specifically encodes the glucose transporter 9 (GLUT9), which plays a crucial role in the renal reabsorption of urate and glucose transport. The protein's function is particularly significant in the context of gout and hyperuricemia, conditions characterized by elevated serum urate levels. Genetic studies have identified several polymorphisms within the SLC2A9 gene that are associated with urate levels and the risk of developing gout. Furthermore, SLC2A9 has been implicated in the regulation of glucose homeostasis, suggesting its potential as a target for metabolic disorder treatments. Research on recombinant SLC2A9 protein has enabled a deeper understanding of its structural and functional properties, facilitating the elucidation of its transport mechanisms. Additionally, studies utilizing this recombinant protein have provided insights into its interaction with various metabolites and pharmacological agents, thus paving the way for novel therapeutic strategies in managing conditions related to dysregulated urate and glucose levels. The ongoing investigation into SLC2A9 is poised to enhance our understanding of its physiological significance and therapeutic potential in metabolic and renal disorders.
