Rabbit Polyclonal PLEK Antibody

The PLEK (pleckstrin homology domain-containing) family of proteins, including members like PLEKHA1. PLEKHB2. and PLEKHG, are characterized by their conserved pleckstrin homology (PH) domains, which mediate interactions with lipid membranes or signaling molecules. Antibodies targeting PLEK proteins have become essential tools in studying their roles in cellular processes such as membrane trafficking, cytoskeletal organization, and intracellular signaling. These proteins are implicated in diverse physiological and pathological contexts, including immune regulation, cancer progression, and neurological disorders. For example, PLEKHA1 is linked to exosome biogenesis, while PLEKHG5 mutations are associated with neurodegenerative diseases. PLEK-specific antibodies enable researchers to detect protein expression, localization, and post-translational modifications via techniques like Western blotting, immunofluorescence, and flow cytometry. Challenges in antibody development include ensuring specificity due to structural similarities among PH domains. Advances in recombinant antibody technology and epitope mapping have improved their precision. Commercial availability of PLEK antibodies has facilitated research into their functional mechanisms and therapeutic potential. Recent studies also explore their diagnostic utility, such as PLEKHB2 as a biomarker in certain cancers. Validation via knockout cell lines or siRNA remains critical to confirm antibody reliability. Overall, PLEK antibodies continue to drive insights into cell biology and disease pathways.