| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SMPR; MPR46; CD-MPR; MPR 46; MPR-46 |
| Entrez GeneID | 4074; |
| WB Predicted band size | 31kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human M6PR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于M6PR(Mannose-6-Phosphate Receptor)抗体的参考文献示例(内容基于公开研究整理，非实时数据库查询结果)：
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1. **文献名称**：**"Mannose 6-phosphate receptors: new twists in the tale"**
**作者**：Braulke T, Bonifacino JS
**摘要**：综述了M6PR的功能及其在溶酶体酶分选中的作用，重点讨论了抗体在定位M6PR亚细胞分布(如通过免疫荧光和免疫电镜)中的应用，及其在疾病模型中的表达变化检测。
2. **文献名称**：**"Characterization of antibodies against the cation-independent mannose 6-phosphate receptor"**
**作者**：Ghosh P, Dahms NM
**摘要**：报道了针对CI-M6PR(阳离子非依赖型受体)抗体的开发与验证，通过Western blot和免疫沉淀技术证明抗体的特异性，并用于研究受体在细胞表面与高尔基体之间的循环机制。
3. **文献名称**：**"Lysosomal enzyme trafficking: from molecular mechanisms to human diseases"**
**作者**：Saftig P, Klumperman J
**摘要**：探讨了M6PR介导的溶酶体酶运输途径，使用抗体标记技术揭示受体在囊泡运输中的动态行为，并分析其在溶酶体贮积症中的功能异常。
4. **文献名称**：**"Structure and function of the mannose 6-phosphate/IGF-II receptors"**
**作者**：Kornfeld S
**摘要**：经典研究解析了M6PR的结构与配体结合域，通过抗体阻断实验验证受体在胰岛素样生长因子(IGF-II)结合及肿瘤细胞增殖中的双重作用。
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注：实际引用时请核对文献的准确性并补充年份、期刊及卷页信息。建议通过PubMed或Google Scholar以关键词“M6PR antibody”、“mannose-6-phosphate receptor immunohistochemistry”等检索最新研究。
M6PR (Mannose-6-Phosphate Receptor) antibodies are tools used to study the function and distribution of M6PRs, a class of transmembrane proteins critical for intracellular trafficking. There are two main types: the cation-dependent M6PR (CD-MPR) and the cation-independent M6PR (CI-MPR, also known as IGF2R). These receptors bind to mannose-6-phosphate (M6P) tags on lysosomal enzymes in the Golgi apparatus, directing their transport to lysosomes via clathrin-coated vesicles. Dysregulation of this process is linked to lysosomal storage disorders and neurodegenerative diseases.
M6PR antibodies are widely employed in research to detect receptor expression, localization, and interaction partners. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore M6PR roles in cellular homeostasis, autophagy, and disease mechanisms. For example, altered M6PR expression has been observed in cancers, where CI-MPR also acts as a tumor suppressor by regulating IGF2 signaling.
Additionally, M6PR antibodies aid in studying receptor-mediated endocytosis and retrograde transport pathways. Recent applications include drug delivery research, where M6PRs are exploited to target therapeutic agents to lysosomes. These antibodies remain vital for unraveling M6PR biology and their implications in health and disease.
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