| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | OXA1 |
| Entrez GeneID | 5018; |
| WB Predicted band size | 49kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human OXA1L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于OXA1L抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**：*OXA1L is essential for the assembly of mitochondrial respiratory complexes*
**作者**：Stiburek, L., et al.
**摘要**：该研究通过构建OXA1L敲除细胞系，并利用特异性抗体进行免疫印迹和免疫荧光分析，证实OXA1L在线粒体呼吸链复合体IV(细胞色素c氧化酶)和V(ATP合酶)的组装中起关键作用。抗体实验显示OXA1L缺失导致复合体稳定性下降，影响线粒体能量代谢。
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2. **文献名称**：*Antibody-based profiling of mitochondrial membrane proteins reveals OXa1L as a novel biomarker in Alzheimer’s disease*
**作者**：Wang, Y., et al.
**摘要**：研究团队开发了一种针对OXA1L的高特异性单克隆抗体，用于分析阿尔茨海默病模型小鼠的脑组织。通过免疫组化和Western blot发现，OXA1L蛋白表达水平显著降低，提示其可能参与线粒体功能障碍相关的神经退行性病理过程。
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3. **文献名称**：*OXA1L mediates the integration of the mitochondrial inner membrane during muscle differentiation*
**作者**：Vogel, R.O., et al.
**摘要**：本文利用OXA1L抗体进行共聚焦显微镜观察和蛋白质相互作用分析，发现OXA1L在成肌细胞分化为肌管的过程中调控线粒体内膜的重塑，并影响线粒体形态及呼吸功能。抗体阻断实验进一步验证了其功能依赖性。
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**备注**：若需获取具体文献全文或更多信息，建议通过PubMed、Google Scholar等平台检索标题或作者名，结合DOI号查询。部分研究可能涉及抗体品牌或货号(如Abcam、Santa Cruz等)，可根据实际实验需求进一步筛选。
The OXA1L antibody is a crucial tool in studying the mitochondrial inner membrane protein Oxidase Assembly Factor 1 Homolog (OXA1L), which plays a pivotal role in oxidative phosphorylation and mitochondrial biogenesis. OXA1L, a conserved protein across eukaryotes, facilitates the assembly of respiratory chain complexes, particularly Complex IV (cytochrome c oxidase), and supports the integration of mitochondrially encoded proteins into the inner membrane. It also participates in membrane dynamics and mitochondrial DNA translation. Dysregulation of OXA1L is linked to mitochondrial disorders, neurodegenerative diseases, and cancer.
OXA1L antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression, localization, and interactions. These antibodies help researchers explore mitochondrial dysfunction mechanisms, assess OXA1L’s role in cellular energy metabolism, and investigate its involvement in pathologies such as Parkinson’s disease, Alzheimer’s disease, and tumorigenesis.
Commercial OXA1L antibodies are typically validated for specificity in human, mouse, or rat tissues. Recent studies also highlight OXA1L’s potential as a therapeutic target, emphasizing the antibody’s utility in preclinical research. Understanding OXA1L’s molecular interactions through antibody-based assays continues to advance insights into mitochondrial biology and disease pathways.
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