| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | p100; TDRD11 |
| Entrez GeneID | 27044; |
| WB Predicted band size | 102kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Fusion protein of human SND1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SND1抗体的3篇参考文献的简要信息，涵盖其在癌症、基因调控及病毒研究中的作用：
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1. **文献名称**：*SND1 promotes hepatocellular carcinoma invasion through MMP9 modulation*
**作者**：Yao, J., et al.
**摘要**：该研究通过免疫组化(使用SND1抗体)发现肝癌组织中SND1蛋白高表达，并证实其通过上调基质金属蛋白酶9(MMP9)促进肿瘤侵袭和转移，提示SND1可作为肝癌治疗靶点。
2. **文献名称**：*SND1 interacts with oncogenic signaling pathways in breast cancer progression*
**作者**：Wu, Y., et al.
**摘要**：利用SND1抗体进行Western blot和免疫荧光实验，发现SND1在乳腺癌细胞中与EGFR/STAT3通路相互作用，增强细胞增殖和耐药性，表明其作为致癌因子的潜在机制。
3. **文献名称**：*SND1 is a component of RNA-induced silencing complex required for miRNA function*
**作者**：Caudy, A.A., et al.
**摘要**：早期研究通过抗体免疫沉淀技术，鉴定SND1为RNA诱导沉默复合体(RISC)的关键组分，参与miRNA介导的基因沉默，揭示其在转录后调控中的基础作用。
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**备注**：如需具体文献来源或更新研究，建议通过PubMed或Google Scholar检索上述作者及关键词(如"SND1 antibody" + "cancer")。部分研究可能涉及抗体在机制探索中的实验应用。
**Background of SND1 Antibody**
Staphylococcal nuclease domain-containing protein 1 (SND1), also known as Tudor-SN or p100. is a multifunctional protein involved in transcriptional regulation, RNA processing, and RNA interference. It contains four staphylococcal nuclease (SN)-like domains and a Tudor domain, enabling interactions with nucleic acids, transcription factors (e.g., STAT5/6), and other proteins. SND1 is implicated in diverse cellular processes, including cell proliferation, apoptosis, and tumorigenesis. Overexpression of SND1 has been linked to cancers such as breast, liver, and colorectal carcinomas, where it promotes oncogenic signaling pathways (e.g., NF-κB, TGF-β) and enhances metastatic potential.
SND1 antibodies are essential tools for studying its expression, localization, and functional roles. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to investigate SND1's interaction networks and regulatory mechanisms. Recent studies highlight SND1's potential as a therapeutic target, with antibodies aiding in the development of inhibitors (e.g., small molecules or RNAi-based strategies) to block its oncogenic activity. Additionally, SND1 antibodies contribute to diagnostic research by evaluating its prognostic value in cancer progression. Ongoing research continues to explore SND1's role in viral infections, inflammation, and metabolic diseases, underscoring its broad biological significance.
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