Rabbit Polyclonal TCN2 Antibody

The TCN2 antibody targets transcobalamin 2 (TCN2), a glycoprotein essential for transporting vitamin B12 (cobalamin) into cells. TCN2 binds to dietary B12 in the bloodstream, forming a complex that interacts with cell surface receptors to mediate cellular uptake. This process is critical for DNA synthesis, red blood cell formation, and neurological function. Dysregulation of TCN2 is linked to genetic disorders like transcobalamin deficiency, which causes megaloblastic anemia, immunodeficiency, and developmental delays. TCN2 antibodies are vital tools in research and diagnostics, enabling the detection of TCN2 expression in tissues or biofluids via techniques such as Western blot, ELISA, and immunohistochemistry. They help elucidate TCN2's role in diseases, including cancer (where altered B12 metabolism may influence tumor progression) and autoimmune conditions. Recent studies also explore TCN2's involvement in age-related and inflammatory disorders, highlighting its broader physiological impact. Commercially available TCN2 antibodies vary in specificity, with validation often confirmed using knockout controls or competitive assays. Researchers prioritize antibodies with high affinity and minimal cross-reactivity to ensure accurate quantification in clinical or experimental settings. Ongoing work aims to refine TCN2-targeted therapies and biomarkers for early disease detection.