| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | BMP8A; Bone morphogenetic protein 8A; BMP-8A |
| Entrez GeneID | 353500; |
| WB Predicted band size | 44kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human BMP-8A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于BMP-8A抗体的3篇参考文献的简要信息(注：文献为虚拟示例，实际引用需核实数据库)：
1. **文献名称**：*BMP-8A regulates mesenchymal stem cell differentiation in bone repair*
**作者**：Chen L, et al.
**摘要**：研究利用BMP-8A特异性抗体分析其在骨折修复中的作用，发现BMP-8A通过激活Smad通路促进间充质干细胞的成骨分化，提示其作为骨再生治疗的潜在靶点。
2. **文献名称**：*Role of BMP-8A in testicular development and spermatogenesis*
**作者**：Wang Y, et al.
**摘要**：通过免疫组化(BMP-8A抗体)和基因敲除模型，揭示BMP-8A在睾丸支持细胞中的高表达，调控精子发生微环境，缺陷可导致雄性不育。
3. **文献名称**：*BMP-8A antibody attenuates hepatic fibrosis by targeting TGF-β crosstalk*
**作者**：Kim S, et al.
**摘要**：开发BMP-8A中和抗体并用于肝纤维化模型，证明其通过抑制TGF-β/Smad3通路减少胶原沉积，为抗纤维化治疗提供新策略。
如需实际文献，建议在PubMed等平台检索“BMP8A antibody”或结合具体研究领域筛选。
The BMP-8A (Bone Morphogenetic Protein 8A) antibody is a tool used to detect and study the BMP-8A protein, a member of the TGF-β (transforming growth factor-beta) superfamily. BMP-8A plays critical roles in embryonic development, tissue homeostasis, and cellular differentiation, particularly in reproductive and skeletal systems. It signals through serine/threonine kinase receptors (Type I/II), activating SMAD-dependent pathways to regulate gene expression. Dysregulation of BMP-8A is implicated in developmental disorders, fibrosis, and cancer progression.
BMP-8A antibodies, either polyclonal or monoclonal, are designed to target specific epitopes of the protein for applications like Western blotting, immunohistochemistry, or ELISA. These antibodies enable researchers to investigate BMP-8A's spatial expression, interaction partners, and functional mechanisms in physiological and pathological contexts. Validation includes specificity checks using knockout controls and cross-reactivity assessments. Recent studies highlight BMP-8A's potential in tissue regeneration and as a biomarker, driving demand for reliable antibodies to advance therapeutic and diagnostic research.
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