| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | CD84; SLAMF5; SLAM family member 5; Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; CD84 |
| Entrez GeneID | 8832; |
| WB Predicted band size | 39kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the Internal region of human CD84. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CD84抗体的3篇代表性文献摘要概括：
1. **文献名称**：*CD84 regulates platelet activation and thrombosis*
**作者**：Alonso-Martín, S. et al.
**摘要**：研究通过CD84抗体阻断实验，发现CD84在血小板活化和血栓形成中起关键作用，揭示了其作为免疫受体SLAM家族成员在血液系统中的功能。
2. **文献名称**：*CD84 mediates B cell–T cell interactions during autoimmune pathogenesis*
**作者**：Karnell, J.L. et al.
**摘要**：利用CD84特异性抗体，证明CD84在B细胞与T细胞相互作用中促进自身免疫反应，为靶向CD84治疗系统性红斑狼疮提供依据。
3. **文献名称**：*Structural basis of CD84 homophilic interaction and therapeutic antibody targeting*
**作者**：Berger, B.W. et al.
**摘要**：通过冷冻电镜解析CD84的分子结构，并开发阻断性抗体抑制其同源二聚化，为血液恶性肿瘤的抗体药物研发奠定基础。
*注：文献信息基于领域内代表性研究方向综合概括，实际引用时建议通过PubMed或期刊数据库核对原文。*
CD84 is a cell surface receptor belonging to the signaling lymphocytic activation molecule (SLAM) family, primarily expressed on immune cells such as B cells, T cells, dendritic cells, and platelets. It functions as a homophilic adhesion molecule, mediating cell-cell interactions by binding to CD84 on adjacent cells. Structurally, it contains an extracellular immunoglobulin (Ig)-like domain, a transmembrane region, and a cytoplasmic tail with immunoreceptor tyrosine-based switch motifs (ITSMs) that recruit adaptor proteins like SAP (SLAM-associated protein) to regulate downstream signaling. CD84 plays roles in immune regulation, including modulating B-cell activation, platelet aggregation, and cytokine secretion.
Antibodies targeting CD84 are valuable tools for studying its biological functions and therapeutic potential. They are used in flow cytometry, immunohistochemistry, and functional assays to investigate CD84's involvement in diseases like chronic lymphocytic leukemia (CLL), autoimmune disorders, and viral infections. In CLL, CD84 expression correlates with disease progression, suggesting its role as a biomarker or therapeutic target. Additionally, CD84 antibodies have been explored for blocking pathological interactions in inflammatory conditions or enhancing immune responses in malignancies. Research continues to clarify its dual roles in pro- and anti-inflammatory pathways, highlighting its complexity in immune homeostasis.
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