| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | HDC; Histidine decarboxylase; HDC |
| Entrez GeneID | 3067; |
| WB Predicted band size | 72kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human HDC. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于HDC(组氨酸脱羧酶)抗体的模拟参考文献示例(内容为虚构，仅作格式参考)：
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1. **文献名称**：Development and Validation of a Specific Polyclonal Antibody Against Human Histidine Decarboxylase
**作者**：Smith A, et al.
**摘要**：本研究报道了一种新型兔源多克隆抗体的开发，用于特异性检测人源组氨酸脱羧酶(HDC)。通过免疫印迹(Western blot)和免疫组化验证，该抗体在胃癌细胞系及肥大细胞中显示出高灵敏度和低交叉反应性，为HDC相关病理机制研究提供了可靠工具。
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2. **文献名称**：HDC Expression in Allergic Inflammation: Insights from HDC-Knockout Mouse Models Using Immunohistochemistry
**作者**：Yamamoto K, et al.
**摘要**：通过HDC抗体对HDC基因敲除小鼠的肥大细胞进行免疫组化分析，发现HDC缺失显著抑制组胺合成，并降低过敏模型中炎症反应强度，提示HDC在过敏性疾病中的关键作用。
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3. **文献名称**：Comparative Analysis of Commercial HDC Antibodies for Neuronal Localization Studies
**作者**：Lee J, et al.
**摘要**：系统评估了五种市售HDC抗体的性能，发现部分抗体在石蜡包埋脑组织切片中存在非特异性结合。推荐使用经抗原表位验证的单克隆抗体(克隆号：HDC-3B8)进行神经元HDC定位研究。
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4. **文献名称**：HDC as a Biomarker in Gastrointestinal Neuroendocrine Tumors: A Clinicopathological Study
**作者**：Garcia R, et al.
**摘要**：利用HDC抗体对150例胃肠神经内分泌肿瘤样本进行染色，结果显示HDC高表达与肿瘤侵袭性和患者预后不良相关，提示其作为潜在治疗靶点的价值。
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**注**：以上文献为示例性内容，实际引用需检索PubMed、Web of Science等数据库获取真实文献。如需进一步协助文献检索，请提供更多具体方向。
Histidine decarboxylase (HDC) is the enzyme responsible for catalyzing the conversion of histidine to histamine, a critical biogenic amine involved in immune regulation, gastric acid secretion, and neurotransmission. HDC antibodies are immunological tools specifically designed to detect and quantify this enzyme in research and diagnostic contexts. These antibodies play a key role in studying histamine-related physiological and pathological processes, including allergic reactions, inflammation, and gastrointestinal disorders.
HDC is expressed in various cell types, such as mast cells, basophils, and enterochromaffin-like (ECL) cells. Its dysregulation has been linked to conditions like mastocytosis, peptic ulcers, and certain cancers. HDC antibodies enable researchers to localize and measure HDC protein expression through techniques like immunohistochemistry, Western blotting, or ELISA. This aids in understanding histamine biosynthesis pathways and evaluating therapeutic targets for histamine-mediated diseases.
Recent studies also explore HDC's role in the tumor microenvironment, where histamine may influence cancer progression. However, challenges remain, including ensuring antibody specificity due to structural similarities with other decarboxylases. Advances in monoclonal antibody development have improved precision, supporting both basic research and clinical applications, such as biomarker identification or monitoring treatment efficacy in histamine-dependent disorders.
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