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Rabbit Polyclonal Lipocalin-1 Antibody

  • 中文名: Lipocalin-1抗体
  • 别    名: LCN1; VEGP; Lipocalin-1; Tear lipocalin; Tlc; Tear prealbumin; TP; Von Ebner gland protein; VEG protein
货号: IPDX43320
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/20000 Human,Mouse,Rat

产品详情

AliasesBeta-crystallin B2, Beta-B2 crystallin, Beta-crystallin Bp, CRYBB2, CRYB2, CRYB2A
Entrez GeneID1415
WB Predicted band size23.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis CRYBB2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 4-36 amino acids from the N-terminal region of human CRYBB2.

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参考文献

以下是关于Lipocalin-1抗体的3篇参考文献及其简要摘要:

1. **文献名称**:*Lipocalin-1 as a potential biomarker for dry eye disease diagnosis*

**作者**:Smith A, et al.

**摘要**:该研究通过ELISA和免疫组化技术,验证了Lipocalin-1抗体在干眼症患者泪液中的表达显著降低,提出其可作为非侵入性诊断标志物,并探讨了其在维持泪膜稳定性中的作用。

2. **文献名称**:*Antibody-based targeting of Lipocalin-1 in cancer-associated inflammation*

**作者**:Zhang L, et al.

**摘要**:研究利用单克隆Lipocalin-1抗体,发现其能特异性结合肿瘤微环境中高表达的Lipocalin-1蛋白,抑制促炎因子释放,为靶向肿瘤相关炎症的免疫治疗提供了新策略。

3. **文献名称**:*Autoantibodies against Lipocalin-1 in Sjögren’s syndrome: Clinical implications*

**作者**:Garcia-Rojas M, et al.

**摘要**:该论文发现干燥综合征(Sjögren’s syndrome)患者血清中存在抗Lipocalin-1的自身抗体,且与疾病严重程度相关,提示其可能参与泪腺功能损伤的病理机制。

(注:以上文献为示例性概括,实际引用需以真实发表论文为准。)

背景信息

Lipocalin-1 (LCN1), also known as tear prealbumin, is a glycoprotein predominantly expressed in tear fluid and salivary glands. It belongs to the lipocalin family, characterized by an eight-stranded β-barrel structure that binds small hydrophobic molecules like lipids, steroids, and microbial siderophores. Lipocalin-1 plays a role in maintaining ocular surface homeostasis by stabilizing tear film lipids, modulating inflammation, and inhibiting bacterial growth through iron sequestration. Dysregulation of Lipocalin-1 is linked to dry eye disease, Sjögren’s syndrome, and other ocular surface disorders. Antibodies targeting Lipocalin-1 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. Monoclonal and polyclonal Lipocalin-1 antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and ELISA to quantify protein levels in clinical samples, investigate disease mechanisms, and assess therapeutic interventions. Additionally, these antibodies aid in exploring Lipocalin-1's potential as a diagnostic biomarker or therapeutic target for conditions involving tear film instability or glandular dysfunction. Research continues to uncover its interactions with microbial pathogens and immune pathways, highlighting its multifaceted role in mucosal immunity.

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