| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | PSG1; B1G1; PSBG1; PSGGA; Pregnancy-specific beta-1-glycoprotein 1; PS-beta-G-1; PSBG-1; Pregnancy-specific glycoprotein 1; CD66 antigen-like family member F; |
| Entrez GeneID | 5669; |
| WB Predicted band size | 46kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human PSG1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于PSG1抗体的参考文献示例(注：以下为虚构内容，建议通过学术数据库核实真实文献)：
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1. **文献名称**: *"Monoclonal antibody targeting PSG1 inhibits tumor growth by modulating immune suppression in colorectal cancer"*
**作者**: Zhang, Y. et al.
**摘要**: 该研究开发了一种靶向PSG1的单克隆抗体，证明其可通过阻断PSG1与肿瘤相关巨噬细胞的相互作用，减轻免疫抑制微环境，从而抑制结直肠癌的生长。
2. **文献名称**: *"PSG1-specific antibodies as diagnostic markers for preeclampsia: a prospective cohort study"*
**作者**: Gupta, R.K. & Alvarez, M.
**摘要**: 文章报道了一种基于抗PSG1抗体的ELISA检测方法，发现妊娠期PSG1水平异常与子痫前期风险显著相关，提示其作为生物标志物的潜力。
3. **文献名称**: *"Structural characterization of PSG1 and its interaction with therapeutic antibodies"*
**作者**: Müller, S. et al.
**摘要**: 通过冷冻电镜解析了PSG1的蛋白结构，并筛选出可特异性结合其抗原表位的治疗性抗体，为开发针对妊娠相关疾病的抗体药物奠定基础。
4. **文献名称**: *"PSG1 antibody-drug conjugate demonstrates efficacy in ovarian cancer models"*
**作者**: Chen, L. et al.
**摘要**: 研究构建了PSG1抗体-药物偶联物(ADC)，在卵巢癌小鼠模型中显示显著抑制肿瘤转移，并揭示了抗体靶向递送化疗药物的机制。
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如需真实文献，建议在 **PubMed** 或 **Web of Science** 中检索关键词(如"PSG1 antibody"、"Pregnancy-Specific Glycoprotein 1 therapeutic")，并筛选近年的研究或综述。
The PSG1 (Pregnancy-Specific Glycoprotein 1) antibody targets a glycoprotein belonging to the carcinoembryonic antigen (CEA) family, primarily expressed during pregnancy. PSG1 is one of 10 human PSGs encoded by genes on chromosome 19q13.2. playing critical roles in immune modulation and maternal-fetal interface regulation. These glycoproteins are secreted by placental syncytiotrophoblasts, with expression peaking in late gestation. PSG1 is characterized by an N-terminal immunoglobulin variable-like domain and heavy glycosylation, which may influence its interaction with receptors like CD209 or Tim-3. contributing to immunosuppressive functions such as promoting anti-inflammatory cytokine secretion or T-cell tolerance.
PSG1 antibodies are essential tools for studying placental development, pregnancy-related pathologies (e.g., preeclampsia), and ectopic PSG1 expression in cancers (e.g., colorectal, lung). They enable detection via ELISA, immunohistochemistry, or Western blot, aiding in biomarker discovery. Recent research explores PSG1's role in tumor immune evasion, positioning it as a potential therapeutic target. However, cross-reactivity with other PSG family members due to structural homology remains a challenge, necessitating careful validation for specificity. Commercial antibodies are typically monoclonal or polyclonal, generated using recombinant protein fragments or synthetic peptides. Further studies are needed to fully elucidate PSG1's signaling mechanisms and clinical applications in obstetrics and oncology.
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