Rabbit Polyclonal Septin8 Antibody

The septin family comprises GTP-binding proteins involved in diverse cellular processes, including cytokinesis, membrane remodeling, and cilia formation. Septin 8 (SEPT8), a member of this conserved protein family, plays roles in neuronal development, intracellular transport, and maintaining cytoskeletal architecture. It forms hetero-oligomeric complexes with other septins, contributing to their structural and regulatory functions. Antibodies targeting SEPT8 are essential tools for studying its expression, localization, and interactions in both physiological and pathological contexts. These antibodies, typically generated in rabbits or mice using immunogenic peptide sequences specific to SEPT8. are validated via techniques like Western blotting, immunofluorescence, and immunoprecipitation. They help identify SEPT8’s involvement in neurodegenerative disorders (e.g., Alzheimer’s disease), cancer (e.g., altered expression in tumors), and infections (e.g., host-pathogen interactions). Specificity is confirmed using knockout controls or siRNA-mediated knockdown. Commercial SEPT8 antibodies often cite applications in brain tissue studies due to its neuronal enrichment. Research utilizing these reagents has expanded insights into septin-related mechanisms, such as synaptic vesicle trafficking and autophagy regulation. However, cross-reactivity with other septins or isoforms requires careful validation. Overall, SEPT8 antibodies remain pivotal in elucidating its cell biological roles and disease associations.