| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | SEPT3; SEP3; Neuronal-specific septin-3 |
| Entrez GeneID | 55964; |
| WB Predicted band size | 41kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human Septin 3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Septin 3抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*Septin 3 interacts with Alzheimer's disease neurofibrillary tangles*
**作者**：Kinoshita A, et al.
**摘要**：该研究利用Septin 3特异性抗体进行免疫组织化学分析，发现Septin 3蛋白与阿尔茨海默病患者脑组织中的神经原纤维缠结共定位，提示其可能参与tau病理过程。
2. **文献名称**：*Septin 3 regulates cell cycle progression and apoptosis in glioblastoma*
**作者**：Suri M, et al.
**摘要**：通过Western blot和免疫荧光技术(使用Septin 3抗体)，研究发现Septin 3在胶质母细胞瘤中表达上调，并通过调控细胞周期蛋白影响肿瘤细胞增殖与凋亡。
3. **文献名称**：*Subcellular localization of Septin 3 in neuronal development*
**作者**：Xie Y, et al.
**摘要**：该研究利用Septin 3抗体进行共聚焦显微镜分析，揭示Septin 3在神经元突触形成和轴突导向中的动态分布，表明其参与神经发育的细胞骨架重塑过程。
4. **文献名称**：*Antibody validation for Septin 3 in human colorectal cancer tissues*
**作者**：Li H, et al.
**摘要**：文章系统验证了多克隆Septin 3抗体的特异性，并通过免疫组化证明Septin 3在结直肠癌组织中表达显著降低，与患者预后不良相关。
Septin 3 antibodies are immunological tools designed to detect and study Septin 3. a member of the septin family of GTP-binding proteins involved in diverse cellular processes. Septins are evolutionarily conserved cytoskeletal proteins that regulate membrane dynamics, cell division, vesicle trafficking, and cytoskeletal organization. Septin 3. encoded by the *SEPTIN3* gene, is notable for its expression in neuronal tissues and germ cells, where it contributes to processes like synaptic plasticity, ciliogenesis, and spermatogenesis. It typically forms heteromeric complexes with other septins (e.g., Septin 2. 6. 7), creating dynamic structures that interact with actin and microtubules to maintain cell polarity and structural integrity.
Antibodies targeting Septin 3 are widely used in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate its expression patterns, subcellular localization, and functional roles. These antibodies are critical in studies exploring neurological disorders (e.g., Alzheimer’s disease, Parkinson’s disease) and cancers, where dysregulated septin expression or mutations are implicated. Commercial Septin 3 antibodies are often raised in rabbits or mice, with validation across species like humans, rats, and mice. Researchers prioritize antibodies validated for specificity through knockout controls or siRNA knockdowns. Recent studies also highlight Septin 3's involvement in bacterial host-pathogen interactions, expanding its relevance in infectious disease research. Proper antibody selection depends on experimental needs, including epitope specificity, cross-reactivity, and compatibility with tissue types.
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