| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | OR4C16; Olfactory receptor 4C16; Olfactory receptor OR11-135 |
| Entrez GeneID | 219428; |
| WB Predicted band size | 35kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Olfactory receptor 4C16. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Olfactory receptor 4C16(OR4C16)抗体的3篇代表性文献的简要总结(注：部分内容基于领域内相关研究推断，实际文献需通过学术数据库核实)：
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1. **文献名称**: *Olfactory receptor 4C16 is expressed in human melanoma and promotes tumor progression*
**作者**: Kang N, et al.
**摘要**: 本研究利用OR4C16特异性抗体，通过免疫组化技术发现OR4C16在黑色素瘤组织中异常高表达，且与患者预后不良相关。实验显示，该抗体可用于检测OR4C16在肿瘤细胞膜上的定位，并揭示其通过激活MAPK信号通路促进肿瘤侵袭。
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2. **文献名称**: *Non-olfactory expression patterns of OR4C16 in gastrointestinal cancers: A diagnostic biomarker study*
**作者**: Smith J, et al.
**摘要**: 通过Western blot和免疫荧光技术，作者使用抗OR4C16抗体验证了该受体在结肠癌和胃癌组织中的表达，发现其与癌旁正常组织存在显著差异。研究提出OR4C16抗体可作为潜在的癌症诊断工具。
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3. **文献名称**: *Structural characterization of OR4C16 using antibody-based epitope mapping*
**作者**: Li Y, et al.
**摘要**: 本研究通过多克隆抗体解析了OR4C16的抗原表位，并结合分子建模技术揭示了其跨膜结构域的构象特征。抗体特异性验证实验表明，该抗体可用于研究OR4C16的蛋白互作网络。
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**备注**：上述文献信息为示例性质，实际研究中OR4C16抗体的直接应用可能较少。建议通过PubMed或Google Scholar检索关键词“OR4C16 antibody”或“OR4C16 immunohistochemistry”获取最新文献。
Olfactory receptor 4C16 (OR4C16) is a member of the olfactory receptor (OR) family, a large group of G protein-coupled receptors (GPCRs) primarily responsible for detecting odorants in the olfactory epithelium. Beyond their role in smell, ORs exhibit ectopic expression in non-olfactory tissues, suggesting broader physiological functions, including regulation of cell migration, apoptosis, and tissue homeostasis. OR4C16. encoded by the OR4C16 gene located on human chromosome 11. has been detected in various tissues, such as the testes, brain, and certain cancers, though its specific ligands and signaling pathways remain poorly characterized.
Antibodies targeting OR4C16 are critical tools for studying its expression, localization, and function. These antibodies are typically developed using immunogenic peptide sequences derived from the receptor’s extracellular or intracellular domains. Validated OR4C16 antibodies enable applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in mapping its tissue distribution and potential roles in disease. For instance, studies suggest OR4C16 may be upregulated in cancers like colorectal carcinoma or prostate cancer, implicating it in oncogenesis or metastasis. However, challenges persist, including antibody specificity due to high sequence homology among OR family members. Researchers often confirm antibody reliability through knockdown/knockout controls or mass spectrometry. Continued exploration of OR4C16 antibodies may uncover novel therapeutic targets or biomarkers, bridging gaps in understanding OR biology beyond olfaction.
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