| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | SLCO1A2; OATP; OATP1; OATP1A2; SLC21A3; Solute carrier organic anion transporter family member 1A2; OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3 |
| Entrez GeneID | 6579; |
| WB Predicted band size | 80kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human OATP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于OATP1抗体的3篇参考文献及其摘要内容(示例为虚构，仅供参考格式)：
1. **文献名称**：*"Development and Application of a High-Affinity Monoclonal Antibody Against OATP1B1 for Hepatic Transporter Studies"*
**作者**：Tanaka M, et al.
**摘要**：该研究开发了一种针对OATP1B1的高特异性单克隆抗体，并通过免疫印迹和免疫组化验证其在人肝组织中的表达定位。抗体成功用于评估药物性肝损伤中OATP1B1的功能下调。
2. **文献名称**：*"Characterization of a Novel Polyclonal Antibody for OATP1A2: Implications for Intestinal Drug Absorption"*
**作者**：Zhang Y, et al.
**摘要**：研究者报道了一种新型多克隆抗体的制备，用于检测OATP1A2在小肠上皮细胞的表达。抗体验证表明其特异性强，无与其他OATP亚型交叉反应，为研究肠道药物转运机制提供工具。
3. **文献名称**：*"Comparative Evaluation of Commercial OATP1B3 Antibodies in Cancer Cell Lines"*
**作者**：Johnson R, et al.
**摘要**：通过比较多种市售OATP1B3抗体的性能，发现部分抗体在肝癌细胞系中存在非特异性结合。研究强调了抗体验证在肿瘤药物转运研究中的必要性。
(注：上述文献为示例，实际引用需以真实发表的论文为准。建议通过PubMed或Google Scholar以关键词“OATP1 antibody”、“OATP1B1 antibody validation”等检索最新研究。)
OATP1 (Organic Anion Transporting Polypeptide 1), part of the solute carrier organic anion (SLCO) transporter family, plays a critical role in cellular uptake of endogenous compounds and xenobiotics. Primarily expressed in hepatocytes (e.g., OATP1B1/1B3) and other tissues, it mediates sodium-independent transport of amphipathic molecules, including bile acids, hormones (e.g., thyroid hormones), and drugs (e.g., statins, antibiotics). OATP1 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts.
These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cell lines, particularly in liver disease, drug-drug interaction studies, and cancer research. Dysregulation of OATP1 is linked to altered drug pharmacokinetics, cholestasis, and hyperbilirubinemia (e.g., Rotor syndrome). Antibodies targeting specific isoforms (e.g., OATP1B1) help identify genetic polymorphisms affecting drug efficacy/toxicity, such as SLCO1B1 variants influencing statin-induced myopathy.
Clinically, OATP1 antibodies aid in diagnosing transporter-related disorders and evaluating chemotherapeutic resistance, as some cancers overexpress OATP1 to internalize cytotoxic drugs. However, cross-reactivity and isoform specificity challenges require careful validation. Overall, OATP1 antibodies bridge mechanistic research and therapeutic applications, enhancing understanding of membrane transport biology and precision medicine.
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