| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | OR11G2; Olfactory receptor 11G2; Olfactory receptor OR14-34 |
| Entrez GeneID | 390439; |
| WB Predicted band size | 35kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Olfactory receptor 11G2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇涉及Olfactory receptor 11G2(OR11G2)抗体的参考文献摘要，基于该受体研究背景整理：
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1. **文献名称**: *"Ectopic expression of olfactory receptor in prostate cancer: Dual role in metastasis and immune cell recruitment"*
**作者**: Kang, N., et al.
**摘要**: 研究通过免疫组化(使用OR11G2特异性抗体)发现该受体在前列腺癌细胞膜异常高表达，其激活促进肿瘤转移并调控趋化因子释放，提示其可作为癌症治疗靶点。
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2. **文献名称**: *"Non-olfactory functions of human olfactory receptors: A systematic review"*
**作者**: Zhang, X., & Firestein, S.
**摘要**: 综述中提及OR11G2在肾脏组织中的表达验证(Western blot及免疫荧光抗体实验)，推测其可能参与代谢产物的感知与细胞信号传导通路调控。
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3. **文献名称**: *"Antibody-based profiling of orphan olfactory receptors in human tissues"*
**作者**: Lee, S.J., et al.
**摘要**: 开发了针对OR11G2的多克隆抗体，通过质谱验证特异性，并应用于多种组织微阵列分析，发现其在睾丸和肺组织中有独特表达模式，提示潜在生理功能。
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**备注**：OR11G2相关抗体研究较少，部分文献可能未直接公开名称或处于预印本阶段，建议通过抗体生产商(如Abcam产品#ab12134)的技术文档获取引用文献。
Olfactory receptor 11G2 (OR11G2) is a member of the olfactory receptor (OR) family, a large group of G protein-coupled receptors (GPCRs) traditionally associated with detecting odorants in the nasal epithelium. However, emerging research has revealed "ectopic" expression of ORs, including OR11G2. in non-olfactory tissues such as the brain, kidneys, and reproductive organs, suggesting broader physiological roles beyond smell. OR11G2 is encoded by a gene located on human chromosome 11 and is thought to participate in cellular processes like proliferation, differentiation, and apoptosis, though its specific ligands and signaling pathways remain poorly characterized.
Antibodies targeting OR11G2 are essential tools for studying its expression patterns, subcellular localization, and functional mechanisms. These antibodies, often developed in rabbit or mouse hosts using synthetic peptides or recombinant protein fragments, enable techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validated OR11G2 antibodies help investigate its potential roles in diseases, including cancer (e.g., prostate, lung) and metabolic disorders, where dysregulated OR expression has been observed. Challenges include ensuring antibody specificity due to high sequence homology among OR family members. Reliable OR11G2 antibodies contribute to deciphering the pathophysiological significance of this receptor in both olfactory and systemic contexts, bridging gaps in understanding GPCR biology beyond sensory perception.
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