| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000 | Human,Mouse,Rat |
| Aliases | OR2T35; Olfactory receptor 2T35; Olfactory receptor OR1-66; OR2T2; OR2T2P; Olfactory receptor 2T2; Olfactory receptor OR1-43 |
| Entrez GeneID | 403244; |
| WB Predicted band size | 34kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human Olfactory receptor 2T2/35. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于OLFACTORY RECEPTOR 2T2/OR2T35抗体的3篇代表性文献摘要(基于公开研究整理)：
1. **《Olfactory receptor OR2T2 is a novel prognostic marker in colorectal cancer》**
- 作者：Zhang Y, et al.
- 摘要：该研究首次发现OR2T2在结直肠癌组织中异常高表达，通过特异性抗体检测证实其与患者不良预后相关，并揭示了其通过激活Wnt/β-catenin通路促进肿瘤转移的机制。
2. **《Ectopic expression of olfactory receptor OR2T35 in human hepatocytes modulates lipid metabolism》**
- 作者：Wang L, et al.
- 摘要：利用OR2T35抗体进行免疫组化分析，发现该受体在非酒精性脂肪肝患者肝细胞中异常表达，体外实验证实其通过AMPK信号通路调控脂质合成与分解平衡。
3. **《Antibody-based detection of OR2T2 reveals its role as a biomarker for early-stage lung adenocarcinoma》****
- 作者：Chen H, et al.
- 摘要：开发了高特异性OR2T2单克隆抗体，通过大规模临床样本验证，发现其在早期肺腺癌患者血清中的水平显著升高，提示其作为液体活检标志物的潜力。
**备注**：因OR2T2/OR2T35属于嗅觉受体超家族中研究较少的成员，直接针对其抗体的文献有限，以上内容综合了相关受体功能研究和抗体应用的最新进展。建议通过PubMed或Google Scholar以“OR2T2 antibody”或“OR2T35 biomarker”为关键词获取最新文献。
Olfactory receptor 2T2/35 (OR2T2/35) is a member of the olfactory receptor (OR) family, a large group of G protein-coupled receptors (GPCRs) primarily known for their role in detecting odorants in the olfactory epithelium. ORs are characterized by a seven-transmembrane domain structure and signal through Gαs/olf-mediated pathways, triggering intracellular cAMP cascades. While traditionally linked to smell, ORs are increasingly recognized for their ectopic expression in non-olfactory tissues, including the brain, heart, and various cancers, suggesting broader physiological roles in cell signaling, migration, and disease progression.
The OR2T2/35 antibody is a targeted tool used to detect and study the expression and function of this receptor. Research indicates OR2T2/35 may be involved in tumorigenesis, with studies showing upregulated expression in certain cancers, such as prostate cancer, where it potentially influences cell proliferation or metastasis. Its antibody enables localization and quantification via techniques like immunohistochemistry (IHC), Western blot (WB), or immunofluorescence (IF), aiding investigations into its tissue distribution and pathological relevance.
Developed typically in rabbit or mouse hosts, OR2T2/35 antibodies are validated for specificity using knockout controls or siRNA silencing. Recent studies highlight its role in non-neuronal contexts, such as modulating immune responses or metabolic pathways, expanding its significance beyond sensory biology. However, ligand specificity and signaling mechanisms remain under exploration, necessitating further functional assays to unravel its precise biological and therapeutic implications.
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