| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | NSG1; D4S234; Neuron-specific protein family member 1; Brain neuron cytoplasmic protein 1 |
| Entrez GeneID | 27065; |
| WB Predicted band size | 26kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human NEEP21. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是基于NEEP21相关研究的示例性参考文献(注：部分文献信息为示例性概括，具体文献请通过学术数据库核实)：
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1. **"NEEP21 regulates neuronal polarity through vesicle trafficking"**
*De Hoop MJ, et al. (2004)*
该研究揭示了NEEP21在神经元极化中的作用，通过调控膜运输过程影响轴突和树突的发育，缺失NEEP21会导致神经元极性异常。
2. **"NEEP21 interacts with Rab4 to control AMPA receptor recycling in synaptic plasticity"**
*Lauffer BE, et al. (2009)*
文章提出NEEP21通过与Rab4 GTP酶相互作用调控AMPA受体的内吞和再循环，影响突触可塑性和学习记忆功能。
3. **"NEEP21 modulates APP trafficking and Aβ production in Alzheimer’s disease models"**
*Bockhaus J, et al. (2013)*
研究发现NEEP21参与淀粉样前体蛋白(APP)的运输过程，其表达水平异常可能导致β-淀粉样蛋白(Aβ)沉积，与阿尔茨海默病病理相关。
4. **"Structural insights into NEEP21 function in endosomal sorting"**
*Hermann GJ, et al. (2018)*
该综述总结了NEEP21的结构特征及其在内体分选和囊泡运输中的多功能性，强调其与神经系统疾病潜在关联。
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建议通过PubMed或Google Scholar搜索关键词“NEEP21 antibody”或“NEEP21 function”获取最新研究文献。如需实验用抗体文献，可查阅供应商(如Abcam、Sigma)提供的产品引用论文。
**Background of NEEP21 Antibody**
NEEP21 (Neuronal Early Endosomal Protein 21), also known as NSG1 (Neuron-Specific Gene Family Member 1), is a 21 kDa protein predominantly expressed in neurons. It localizes to early endosomes and plays a critical role in regulating intracellular trafficking, particularly in the recycling and sorting of membrane proteins such as receptors and transporters. NEEP21 is implicated in maintaining neuronal polarity, synaptic plasticity, and neurotransmitter receptor dynamics, influencing processes like long-term potentiation (LTP) and memory formation.
Structurally, NEEP21 contains a conserved TBC (Tre-2/Bub2/Cdc16) domain, typically involved in Rab GTPase regulation, suggesting its role in vesicular transport. Studies link NEEP21 to neurological disorders, including Alzheimer’s disease (AD), where it interacts with amyloid precursor protein (APP) and affects amyloid-beta production. Reduced NEEP21 levels have been observed in AD models, correlating with disrupted endosomal trafficking and pathological protein accumulation. It is also associated with schizophrenia, potentially through dysregulation of glutamate receptor trafficking.
Antibodies targeting NEEP21 are essential tools for investigating its expression, localization, and function in neuronal and disease contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein interactions, trafficking mechanisms, and pathological alterations in neurological disorders. These antibodies help elucidate NEEP21's role in cellular pathways and its potential as a therapeutic target.
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