Rabbit Polyclonal MINK1 Antibody

The MINK1 (Misshapen-like kinase 1) antibody is a tool used to detect and study the MINK1 protein, a serine/threonine kinase belonging to the germinal center kinase (GCK) family. MINK1 plays a critical role in cellular stress responses, proliferation, differentiation, and apoptosis by regulating MAPK (mitogen-activated protein kinase) signaling pathways. It interacts with downstream targets like JNK (c-Jun N-terminal kinase) and modulates cytoskeletal organization through RAPGEF2-mediated pathways. Researchers utilize MINK1 antibodies in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to explore its expression, localization, and function in various tissues and disease contexts. Studies have linked MINK1 to cancer progression, immune regulation, and neurodegenerative disorders, highlighting its potential as a therapeutic target. The antibody’s specificity is validated using knockout controls or siRNA knockdowns to ensure accurate detection. Commercial MINK1 antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes within its kinase domain or C-terminal regions. Its role in stress-activated signaling and crosstalk with pathways like Hippo-YAP further underscores its biological relevance. Ongoing research aims to clarify its mechanistic contributions to diseases and its utility in diagnostic or therapeutic applications.