| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | MLTK; ZAK; HCCS4; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixe |
| Entrez GeneID | 51776; |
| WB Predicted band size | 91kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the C-terminal region of human MLTK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于MLTK抗体的3篇示例参考文献(注：以下内容为虚构示例，仅用于展示格式)：
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1. **文献名称**: "Development of a High-Affinity Monoclonal Antibody Targeting MLTK for Signal Pathway Analysis"
**作者**: Tanaka H, et al.
**摘要**: 研究团队开发了一种针对MLTK激酶的高特异性单克隆抗体，通过免疫印迹(Western blot)和免疫荧光验证其有效性，用于解析MLTK在MAPK/NF-κB信号通路中的调控机制。
2. **文献名称**: "MLTK-α Antibody Reveals Its Role in Cellular Stress Responses"
**作者**: Zhang Y, et al.
**摘要**: 利用新型多克隆抗体，研究发现MLTK-α在氧化应激和DNA损伤应答中的磷酸化活性，证实其通过激活下游JNK通路参与细胞凋亡。
3. **文献名称**: "Characterization of MLTK Isoforms Using Isoform-Specific Antibodies in Cancer Models"
**作者**: Müller S, et al.
**摘要**: 通过亚型特异性抗体区分MLTK-α和MLTK-β，揭示两者在肿瘤细胞迁移和侵袭中的差异表达及功能，为靶向治疗提供依据。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词**"MLTK antibody"**或**"MLTK kinase antibody"**，并筛选涉及抗体开发、验证或功能研究的文章。
MLTK (Mixed-Lineage Kinase 3-like protein), also known as MAP3K14 or NIK (NF-κB-inducing kinase), is a serine/threonine kinase involved in regulating the non-canonical NF-κB signaling pathway. Structurally, it belongs to the MAP3K family, characterized by a kinase domain and regulatory regions. MLTK activates IKKα (Inhibitor of κB kinase α) by phosphorylating it, which triggers processing of the NF-κB precursor p100 into active p52. This promotes nuclear translocation of p52/RelB complexes, driving gene expression linked to cell survival, proliferation, and immune responses.
MLTK plays critical roles in B-cell maturation, lymphoid organogenesis, and osteoclast differentiation. Dysregulation of MLTK is implicated in autoimmune diseases, chronic inflammation, and cancers, particularly lymphomas and multiple myeloma, where aberrant NF-κB signaling is common. Its activity is tightly controlled by TRAF3 (TNF receptor-associated factor 3), which targets MLTK for proteasomal degradation under resting conditions. Stimuli like CD40. BAFF, or LTβ receptor activation disrupt TRAF3-mediated inhibition, enabling MLTK-dependent NF-κB activation.
Antibodies targeting MLTK are essential tools for studying its expression, phosphorylation status, and interactions in cellular pathways. They are used in Western blotting, immunoprecipitation, and immunohistochemistry to explore MLTK's role in disease mechanisms or therapeutic targeting. Research on MLTK inhibitors highlights its potential as a drug target for NF-κB-driven pathologies, underscoring the importance of specific antibodies in both basic research and drug development.
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