| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | KDELR2; ERD2.2; ER lumen protein retaining receptor 2; ERD2-like protein 1; ELP-1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2 |
| Entrez GeneID | 11014; |
| WB Predicted band size | 24kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human KDEL Receptor 2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于KDEL受体2(KDELR2)抗体的3篇示例文献，内容基于典型研究方向构建：
1. **文献名称**：*KDEL Receptor 2 regulates endoplasmic reticulum homeostasis by modulating the unfolded protein response*
**作者**：Smith A, et al.
**摘要**：本研究利用特异性抗KDELR2抗体，通过免疫荧光和Western blot技术，揭示了KDELR2在内质网未折叠蛋白反应(UPR)中的调控作用，表明其缺失会加剧内质网应激相关的细胞凋亡。
2. **文献名称**：*Antibody-based profiling of KDEL receptors reveals distinct subcellular localization and functional divergence*
**作者**：Chen L, et al.
**摘要**：作者开发了针对KDELR家族(包括KDELR2)的亚型特异性抗体，证实KDELR2主要定位于高尔基体，并参与选择性回收内质网分子伴侣(如BiP)。研究强调了抗体在区分受体亚型功能中的重要性。
3. **文献名称**：*KDELR2 promotes tumor angiogenesis through VEGF secretion and is a therapeutic target in colorectal cancer*
**作者**：Wang Y, et al.
**摘要**：通过抗KDELR2抗体的免疫组化分析，发现KDELR2在结直肠癌中高表达，并通过调控VEGF的分泌促进血管生成。抗体阻断实验表明靶向KDELR2可抑制肿瘤生长。
4. **文献名称**：*Comparative analysis of KDEL receptor isoforms in Drosophila and mammalian cells*
**作者**：Tanaka K, et al.
**摘要**：利用跨物种抗体比较了KDELR2在果蝇和哺乳动物细胞中的保守功能，证明其在分泌蛋白质量监控中的作用，抗体特异性验证支持了进化功能保留的假说。
(注：以上文献为示例，实际引用需根据具体论文调整。)
The KDEL receptor 2 (KDELR2) is a member of the KDEL receptor family, which plays a critical role in the retrieval of endoplasmic reticulum (ER)-resident proteins that escape to the Golgi apparatus. These receptors recognize proteins containing a C-terminal KDEL (Lys-Asp-Glu-Leu) or similar signal sequence, facilitating their return to the ER via COPI-coated vesicles. KDELR2. one of three mammalian isoforms (KDELR1-3), is a seven-transmembrane domain protein localized primarily to the Golgi membrane. It contributes to maintaining ER homeostasis by ensuring proper protein folding and quality control.
Antibodies targeting KDELR2 are essential tools for studying its expression, localization, and function in cellular and pathological contexts. These antibodies are typically developed in host species like rabbits or mice using immunogenic peptides or recombinant protein fragments. They enable detection of KDELR2 in techniques such as Western blotting, immunofluorescence, and immunohistochemistry. Specificity is validated through knockdown or knockout controls to distinguish KDELR2 from other isoforms. Research using KDELR2 antibodies has linked the receptor to diseases like cancer and neurodegeneration, where disrupted ER protein retrieval may contribute to pathogenesis. Additionally, these antibodies aid in exploring KDELR2's role in cellular stress responses and secretory pathway regulation.
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