| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ITPKC; IP3KC; Inositol-trisphosphate 3-kinase C; Inositol 1; 4,5-trisphosphate 3-kinase C; IP3 3-kinase C; IP3K C; InsP 3-kinase C |
| Entrez GeneID | 80271; |
| WB Predicted band size | 102kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human InsP 3-kinase C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于InsP3-kinase C(IP3K-C)抗体的3篇参考文献，按文献名称、作者和摘要内容概括：
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1. **文献名称**：*"Characterization of InsP3-kinase C monoclonal antibody for detecting isoform-specific expression in cancer cells"*
**作者**：Smith A, et al.
**摘要**：该研究开发了一种针对IP3K-C的单克隆抗体，验证了其在Western blot和免疫荧光中的特异性，发现IP3K-C在乳腺癌细胞中高表达，并与细胞迁移相关。
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2. **文献名称**：*"InsP3-kinase C regulates T cell activation through antibody-mediated localization studies"*
**作者**：Zhang L, et al.
**摘要**：利用IP3K-C特异性抗体，研究发现该激酶在T细胞活化过程中向免疫突触聚集，调控钙信号通路，影响IL-2分泌和细胞增殖。
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3. **文献名称**：*"IP3K-C antibody reveals its role in neuronal calcium signaling and synaptic plasticity"*
**作者**：Tanaka K, et al.
**摘要**：通过免疫组织化学和共聚焦显微镜，该文献证明IP3K-C在小鼠海马神经元中富集，其活性依赖钙振荡，并参与长时程增强(LTP)的调控。
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**备注**：以上文献为示例，实际引用时需核对真实发表的论文标题、作者及内容。建议通过PubMed或Google Scholar以关键词“IP3K-C antibody”“InsP3K-C”或“IP3K3”检索近十年相关研究。
InsP₃-kinase C (IP3K-C), encoded by the ITPKC gene, is a member of the inositol 1.4.5-trisphosphate (InsP₃) kinase family that phosphorylates InsP₃ to generate inositol 1.3.4.5-tetrakisphosphate (InsP₄). This enzyme plays a critical role in modulating intracellular calcium signaling by regulating the balance between InsP₃ and InsP₄, which influences calcium release from endoplasmic reticulum stores. IP3K-C is involved in diverse cellular processes, including immune response regulation, apoptosis, and cell proliferation. Dysregulation of IP3K-C has been linked to pathologies such as inflammatory diseases, cancer, and Kawasaki disease, where altered calcium signaling contributes to disease progression.
Antibodies targeting IP3K-C are essential tools for studying its expression, localization, and function in biological systems. These antibodies enable detection of IP3K-C in techniques like Western blotting, immunohistochemistry, and immunofluorescence. They are particularly valuable in research exploring calcium-dependent signaling pathways or IP3K-C's role in disease mechanisms. Commercially available IP3K-C antibodies are typically raised against specific epitopes, such as peptide sequences from the N-terminal or catalytic domains, and may vary in species reactivity (e.g., human, mouse, rat). Validation often includes testing in knockout models or siRNA-treated cells to confirm specificity. Reliable IP3K-C antibodies are crucial for advancing studies on calcium signaling dysregulation and therapeutic targeting in related disorders.
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