| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | ITGA3; MSK18; Integrin alpha-3; CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD antigen CD49c |
| Entrez GeneID | 3675; |
| WB Predicted band size | 150kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human Integrin α3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Integrin α3抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: "Integrin α3β1 is a critical regulator of vascular development"
**作者**: Kreidberg JA, et al.
**摘要**: 该研究利用Integrin α3特异性抗体，发现α3β1在血管内皮细胞发育中起关键作用，基因敲除或抗体阻断会导致小鼠胚胎血管结构异常，提示其参与细胞-基质黏附及血管生成信号传导。
2. **文献名称**: "Role of integrin α3 in melanoma progression and metastasis"
**作者**: Morini M, et al.
**摘要**: 通过抗Integrin α3抗体抑制实验，研究发现α3在黑色素瘤细胞侵袭和转移中促进层粘连蛋白结合，并调控金属蛋白酶(MMP)分泌，表明其可作为肿瘤治疗的潜在靶点。
3. **文献名称**: "Integrin α3 regulates epithelial cell polarity via interactions with laminin"
**作者**: Tsuruta D, et al.
**摘要**: 使用Integrin α3抗体进行免疫荧光定位，发现α3β1通过与基底膜层粘连蛋白结合维持上皮细胞极性，缺失导致皮肤组织极性紊乱，揭示其在组织稳态中的功能。
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以上研究均通过Integrin α3抗体验证其在疾病机制或生理过程中的作用，涵盖发育生物学、肿瘤学及细胞生物学领域。
Integrin α3 antibody is a research tool targeting the α3 subunit of integrins, a family of cell adhesion receptors critical for cell-extracellular matrix (ECM) interactions. Integrin α3 typically pairs with the β1 subunit to form the α3β1 heterodimer, which acts as a receptor for laminin, collagen, and other ECM components. This integrin is expressed in epithelial, endothelial, and neuronal cells, playing roles in cell adhesion, migration, signaling, and tissue morphogenesis. It is implicated in processes like wound healing, embryonic development, and cancer progression, where its dysregulation may promote tumor invasion or metastasis.
Antibodies against integrin α3 are widely used to study its expression, localization, and function in physiological and pathological contexts. For example, they help assess α3β1 levels in cancer biopsies to explore correlations with disease aggressiveness or patient prognosis. In research settings, these antibodies are applied in techniques like Western blotting, immunohistochemistry, and flow cytometry. Additionally, they aid in elucidating α3β1's dual roles in certain cancers—acting as either a tumor suppressor or promoter depending on cellular context—and its involvement in kidney or skin disorders linked to genetic mutations. Studies using integrin α3 antibodies also contribute to understanding cell-ECM signaling crosstalk and potential therapeutic targeting of integrin-mediated pathways.
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